Investigation of cardiotoxic effects of marbofloxacin
<b>Aim: </b>The primary objective of the present research is to determine the cardiotoxic effect of marbofloxacin by measuring of serum troponin I, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels which are cardiotoxic damage markers. In...
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| Format: | Article |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1242 |
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| author | Devran Coşkun Burak Dik Yasemin Korkmaz Rahmi Canbar Ayşe Er Enver Yazar |
| author_facet | Devran Coşkun Burak Dik Yasemin Korkmaz Rahmi Canbar Ayşe Er Enver Yazar |
| author_sort | Devran Coşkun |
| collection | DOAJ |
| description | <b>Aim: </b>The primary objective of the present research is to determine
the cardiotoxic effect of marbofloxacin by measuring of serum troponin
I, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH)
and aspartate aminotransferase (AST) levels which are cardiotoxic
damage markers. In addition, it is to determine the effects of marbofloxacin
on the liver function [alkaline phosphatase (ALP), alanine
aminotransferase (ALT), gamma glutamyltransferase (GGT), total
protein], renal function [blood urea nitrogen (BUN, creatinine] and
hemogram [white blood cell (WBC), red blood cell (RBC), platelet,
hemoglobin, hematocrit] parameters.<p>
<b>Materials and Methods:</b> In the study, 10 Merino yearling received
marbofloxacin (10 mg/kg/day, subcutan) for 14 days. Blood samples
were taken on day 0 (control), 1, 3, 5, 7, 9, 11, 13 and 15 days. Sheep
specific serum CK-MB and troponin I levels were measured with
ELISA reader, while serum LDH, AST, ALT, ALP, GGT, total protein, creatinine
and BUN values were determined with autoanalyser. Hemogram
parameters were determined with hemocell counters, as well.<p>
<b>Results:</b> Marbofloxacin increased cardiac damage markers which
were troponin I, not statistically significant (P>0,05), LDH and AST
levels, statistically significant (P<0,05). While marbofloxacin did not
cause (P<0,05) any adverse effect on liver function parameters, it
caused (P<0,05) increase BUN levels and fluctuations in creatinine
levels which were renal function values. In hemogram parameters, it
caused (P <0,05) temporary decreases close to the reference values.<p>
<b>Conclusion:</b> It can be stated that the when sheep should be treated
with high doses of long-term marbofloxacin, cardiotoxicity should
be taken with caution. However, cardiotoxic effects of marbofloxacin
should be confirmed histopathologically. |
| format | Article |
| id | doaj-art-23d44502b2dd4c55b9699a6f059ea84d |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-23d44502b2dd4c55b9699a6f059ea84d2025-01-02T22:36:23ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-195335256611242Investigation of cardiotoxic effects of marbofloxacinDevran Coşkun0Burak Dik1Yasemin Korkmaz2Rahmi Canbar3Ayşe Er4Enver Yazar5Siirt Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Siirt, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Konya, Türkiye<b>Aim: </b>The primary objective of the present research is to determine the cardiotoxic effect of marbofloxacin by measuring of serum troponin I, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels which are cardiotoxic damage markers. In addition, it is to determine the effects of marbofloxacin on the liver function [alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma glutamyltransferase (GGT), total protein], renal function [blood urea nitrogen (BUN, creatinine] and hemogram [white blood cell (WBC), red blood cell (RBC), platelet, hemoglobin, hematocrit] parameters.<p> <b>Materials and Methods:</b> In the study, 10 Merino yearling received marbofloxacin (10 mg/kg/day, subcutan) for 14 days. Blood samples were taken on day 0 (control), 1, 3, 5, 7, 9, 11, 13 and 15 days. Sheep specific serum CK-MB and troponin I levels were measured with ELISA reader, while serum LDH, AST, ALT, ALP, GGT, total protein, creatinine and BUN values were determined with autoanalyser. Hemogram parameters were determined with hemocell counters, as well.<p> <b>Results:</b> Marbofloxacin increased cardiac damage markers which were troponin I, not statistically significant (P>0,05), LDH and AST levels, statistically significant (P<0,05). While marbofloxacin did not cause (P<0,05) any adverse effect on liver function parameters, it caused (P<0,05) increase BUN levels and fluctuations in creatinine levels which were renal function values. In hemogram parameters, it caused (P <0,05) temporary decreases close to the reference values.<p> <b>Conclusion:</b> It can be stated that the when sheep should be treated with high doses of long-term marbofloxacin, cardiotoxicity should be taken with caution. However, cardiotoxic effects of marbofloxacin should be confirmed histopathologically.http://eurasianjvetsci.org/pdf.php3?id=1242marbofloxacincardiotoxicity |
| spellingShingle | Devran Coşkun Burak Dik Yasemin Korkmaz Rahmi Canbar Ayşe Er Enver Yazar Investigation of cardiotoxic effects of marbofloxacin Eurasian Journal of Veterinary Sciences marbofloxacin cardiotoxicity |
| title | Investigation of cardiotoxic effects of marbofloxacin |
| title_full | Investigation of cardiotoxic effects of marbofloxacin |
| title_fullStr | Investigation of cardiotoxic effects of marbofloxacin |
| title_full_unstemmed | Investigation of cardiotoxic effects of marbofloxacin |
| title_short | Investigation of cardiotoxic effects of marbofloxacin |
| title_sort | investigation of cardiotoxic effects of marbofloxacin |
| topic | marbofloxacin cardiotoxicity |
| url | http://eurasianjvetsci.org/pdf.php3?id=1242 |
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