Investigation of cardiotoxic effects of marbofloxacin
<b>Aim: </b>The primary objective of the present research is to determine the cardiotoxic effect of marbofloxacin by measuring of serum troponin I, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels which are cardiotoxic damage markers. In...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1242 |
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| Summary: | <b>Aim: </b>The primary objective of the present research is to determine
the cardiotoxic effect of marbofloxacin by measuring of serum troponin
I, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH)
and aspartate aminotransferase (AST) levels which are cardiotoxic
damage markers. In addition, it is to determine the effects of marbofloxacin
on the liver function [alkaline phosphatase (ALP), alanine
aminotransferase (ALT), gamma glutamyltransferase (GGT), total
protein], renal function [blood urea nitrogen (BUN, creatinine] and
hemogram [white blood cell (WBC), red blood cell (RBC), platelet,
hemoglobin, hematocrit] parameters.<p>
<b>Materials and Methods:</b> In the study, 10 Merino yearling received
marbofloxacin (10 mg/kg/day, subcutan) for 14 days. Blood samples
were taken on day 0 (control), 1, 3, 5, 7, 9, 11, 13 and 15 days. Sheep
specific serum CK-MB and troponin I levels were measured with
ELISA reader, while serum LDH, AST, ALT, ALP, GGT, total protein, creatinine
and BUN values were determined with autoanalyser. Hemogram
parameters were determined with hemocell counters, as well.<p>
<b>Results:</b> Marbofloxacin increased cardiac damage markers which
were troponin I, not statistically significant (P>0,05), LDH and AST
levels, statistically significant (P<0,05). While marbofloxacin did not
cause (P<0,05) any adverse effect on liver function parameters, it
caused (P<0,05) increase BUN levels and fluctuations in creatinine
levels which were renal function values. In hemogram parameters, it
caused (P <0,05) temporary decreases close to the reference values.<p>
<b>Conclusion:</b> It can be stated that the when sheep should be treated
with high doses of long-term marbofloxacin, cardiotoxicity should
be taken with caution. However, cardiotoxic effects of marbofloxacin
should be confirmed histopathologically. |
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| ISSN: | 1309-6958 2146-1953 |