Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance
Objectives: Subclinical myocardial involvement is common in systemic lupus erythematosus (SLE), but differences between new onset and longstanding SLE are not fully elucidated. This study compared myocardial involvement in new onset versus longstanding SLE using cardiovascular magnetic resonance (CM...
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Elsevier
2025-06-01
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| Series: | European Journal of Radiology Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047724000789 |
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| author | Zhen Wang Xing Tang Chaohui Hang Hui Gao Jinxiu Yang Yuchi Han Yongqiang Yu Zongwen Shuai Ren Zhao Xiaohu Li |
| author_facet | Zhen Wang Xing Tang Chaohui Hang Hui Gao Jinxiu Yang Yuchi Han Yongqiang Yu Zongwen Shuai Ren Zhao Xiaohu Li |
| author_sort | Zhen Wang |
| collection | DOAJ |
| description | Objectives: Subclinical myocardial involvement is common in systemic lupus erythematosus (SLE), but differences between new onset and longstanding SLE are not fully elucidated. This study compared myocardial involvement in new onset versus longstanding SLE using cardiovascular magnetic resonance (CMR). Materials and methods: We prospectively enrolled 24 drug-naïve new onset SLE patients, 27 longstanding SLE patients, and 20 healthy controls. All participants underwent clinical evaluation and CMR examination. We analyzed left ventricular (LV) morphological, functional parameters, and tissue characterization parameters: native T1, T2, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE). Results: Both new onset and longstanding SLE groups showed elevated native T1, T2, and ECV values compared to the control group (all P < 0.05). Additionally, the new onset SLE group exhibited higher T2 values compared to the longstanding SLE group [55.3 vs. 52.8 ms, P < 0.05]. The new onset group also demonstrated higher left ventricular (LV) end-diastolic volume index (LVEDVi), LV end-systolic volume index (LVSVi), and LV mass index (LVMi) than controls (all P < 0.05), with LVEDVi significantly higher than in the longstanding group (P < 0.05). Conclusion: CMR tissue characterization imaging can detect early myocardial involvement in patients with new onset and longstanding SLE. Patients with new onset SLE exhibit more pronounced myocardial edema than those with longstanding SLE. This suggests that SLE patients are at risk of myocardial damage at various stages of the disease, underscoring the need for early monitoring and long-term management to prevent the progression of myocardial remodeling. |
| format | Article |
| id | doaj-art-23cda28542c24d2db8d70fef2c802bec |
| institution | Kabale University |
| issn | 2352-0477 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Radiology Open |
| spelling | doaj-art-23cda28542c24d2db8d70fef2c802bec2024-12-22T05:28:17ZengElsevierEuropean Journal of Radiology Open2352-04772025-06-0114100623Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonanceZhen Wang0Xing Tang1Chaohui Hang2Hui Gao3Jinxiu Yang4Yuchi Han5Yongqiang Yu6Zongwen Shuai7Ren Zhao8Xiaohu Li9Department of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Anhui Province Clinical Image Quality Control Center, No.218 Jixi Road, Hefei, Anhui 230022, China; Research Center of Clinical Medical Imaging, Hefei, Anhui 230022, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Anhui Province Clinical Image Quality Control Center, No.218 Jixi Road, Hefei, Anhui 230022, China; Research Center of Clinical Medical Imaging, Hefei, Anhui 230022, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Anhui Province Clinical Image Quality Control Center, No.218 Jixi Road, Hefei, Anhui 230022, China; Research Center of Clinical Medical Imaging, Hefei, Anhui 230022, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Anhui Province Clinical Image Quality Control Center, No.218 Jixi Road, Hefei, Anhui 230022, China; Research Center of Clinical Medical Imaging, Hefei, Anhui 230022, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Anhui Province Clinical Image Quality Control Center, No.218 Jixi Road, Hefei, Anhui 230022, China; Research Center of Clinical Medical Imaging, Hefei, Anhui 230022, ChinaCardiovascular Division, Wexner Medical Center, College of Medicine, The Ohio State University, 370 W. 9th Avenue, Columbus, OH 43210, United StatesDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Anhui Province Clinical Image Quality Control Center, No.218 Jixi Road, Hefei, Anhui 230022, China; Research Center of Clinical Medical Imaging, Hefei, Anhui 230022, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Corresponding author.Department of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China; Anhui Province Clinical Image Quality Control Center, No.218 Jixi Road, Hefei, Anhui 230022, China; Research Center of Clinical Medical Imaging, Hefei, Anhui 230022, China; Corresponding author at: Department of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, ChinaObjectives: Subclinical myocardial involvement is common in systemic lupus erythematosus (SLE), but differences between new onset and longstanding SLE are not fully elucidated. This study compared myocardial involvement in new onset versus longstanding SLE using cardiovascular magnetic resonance (CMR). Materials and methods: We prospectively enrolled 24 drug-naïve new onset SLE patients, 27 longstanding SLE patients, and 20 healthy controls. All participants underwent clinical evaluation and CMR examination. We analyzed left ventricular (LV) morphological, functional parameters, and tissue characterization parameters: native T1, T2, extracellular volume fraction (ECV), and late gadolinium enhancement (LGE). Results: Both new onset and longstanding SLE groups showed elevated native T1, T2, and ECV values compared to the control group (all P < 0.05). Additionally, the new onset SLE group exhibited higher T2 values compared to the longstanding SLE group [55.3 vs. 52.8 ms, P < 0.05]. The new onset group also demonstrated higher left ventricular (LV) end-diastolic volume index (LVEDVi), LV end-systolic volume index (LVSVi), and LV mass index (LVMi) than controls (all P < 0.05), with LVEDVi significantly higher than in the longstanding group (P < 0.05). Conclusion: CMR tissue characterization imaging can detect early myocardial involvement in patients with new onset and longstanding SLE. Patients with new onset SLE exhibit more pronounced myocardial edema than those with longstanding SLE. This suggests that SLE patients are at risk of myocardial damage at various stages of the disease, underscoring the need for early monitoring and long-term management to prevent the progression of myocardial remodeling.http://www.sciencedirect.com/science/article/pii/S2352047724000789new onset SLElongstanding SLEmyocardial involvementcardiovascular magnetic resonance |
| spellingShingle | Zhen Wang Xing Tang Chaohui Hang Hui Gao Jinxiu Yang Yuchi Han Yongqiang Yu Zongwen Shuai Ren Zhao Xiaohu Li Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance European Journal of Radiology Open new onset SLE longstanding SLE myocardial involvement cardiovascular magnetic resonance |
| title | Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance |
| title_full | Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance |
| title_fullStr | Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance |
| title_full_unstemmed | Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance |
| title_short | Differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance |
| title_sort | differences in myocardial involvement between new onset and longstanding systemic lupus erythematosus patients assessed by cardiovascular magnetic resonance |
| topic | new onset SLE longstanding SLE myocardial involvement cardiovascular magnetic resonance |
| url | http://www.sciencedirect.com/science/article/pii/S2352047724000789 |
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