Pilaralisib inhibits the replication of enteroviruses by targeting the PI3K/AKT signaling pathway

Pilaralisib inhibits the replication of enteroviruses by targeting the PI3K/AKT signaling pathway

Abstract Enterovirus 71 (EV71) is a significant pathogen responsible for hand, foot, and mouth disease (HFMD), which poses a substantial public health concern, particularly in the Asia-Pacific region. The virus is transmitted primarily through the fecal-oral route and via respiratory droplets, enter...

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Bibliographic Details
Main Authors: Jie Zhou, Yanping Wang, Guangyan Zhu, Mingzhe Yan, Zhengnan Li, Lin Li, Jingwen Kuang, Wenyuan Zhang, Chaolin Huang, Fuli Ren, Qingyu Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Virology Journal
Subjects:
EV71
Antiviral agents
PI3K/AKT signaling pathway
Virus replication
HFMD
Online Access:https://doi.org/10.1186/s12985-025-02881-w
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