Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization
ObjectivesThis study aimed to examine the causal relationships between peripheral immune cell counts and prostate cancer, adhering to Mendelian Randomization reporting guidelines for transparency and reproducibility.MethodsIn this study, bidirectional Mendelian randomization (MR) analysis, which inc...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1374927/full |
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| author | Xiaolu Ren Xiaolu Ren Li Zhang Kehua Wang Fang Li |
| author_facet | Xiaolu Ren Xiaolu Ren Li Zhang Kehua Wang Fang Li |
| author_sort | Xiaolu Ren |
| collection | DOAJ |
| description | ObjectivesThis study aimed to examine the causal relationships between peripheral immune cell counts and prostate cancer, adhering to Mendelian Randomization reporting guidelines for transparency and reproducibility.MethodsIn this study, bidirectional Mendelian randomization (MR) analysis, which includes MR-Egger, weighted median, weighted mode, and inverse variance weighted (IVW) approaches, was utilized to evaluate the bidirectional causal relationship between peripheral immune cell counts and the risk of PCa.ResultsThe primary analysis using the IVW method suggests a potential causal association between basophil counts and the risk of prostate cancer (PCa), with an odds ratio (OR) of 1.111 and a 95% confidence interval (CI) of 1.011-1.222 (P = 0.028). Conversely, non-causal associations have been observed between other peripheral immune cell types, such as white blood cells, neutrophils, lymphocytes, eosinophils, or monocytes, and the incidence of PCa (P values > 0.05). Furthermore, although reverse analysis indicated a causal link between PCa and the counts of leukocytes and neutrophils (OR = 1.013; 95% CI = 1.002–1.225; P = 0.018 and OR = 1.013; 95% CI = 1.002–1.025; P = 0.019), no causal association was detected between PCa and basophil count (P value > 0.050).ConclusionThis study suggests a potential bidirectional link between peripheral immune cells and prostate cancer, but inconsistencies in Mendelian Randomization methods mean these findings are preliminary and require further investigation. |
| format | Article |
| id | doaj-art-237e9479f3aa46daa561e65eab37741b |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-237e9479f3aa46daa561e65eab37741b2024-11-29T05:10:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-11-011410.3389/fonc.2024.13749271374927Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomizationXiaolu Ren0Xiaolu Ren1Li Zhang2Kehua Wang3Fang Li4Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan, ChinaSchool of Health Sciences, Universiti Sains Malaysia, Kelantan, MalaysiaDepartment of Urology, People’s Hospital of Wuzhong, Wuzhong, ChinaDepartment of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan, ChinaDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, ChinaObjectivesThis study aimed to examine the causal relationships between peripheral immune cell counts and prostate cancer, adhering to Mendelian Randomization reporting guidelines for transparency and reproducibility.MethodsIn this study, bidirectional Mendelian randomization (MR) analysis, which includes MR-Egger, weighted median, weighted mode, and inverse variance weighted (IVW) approaches, was utilized to evaluate the bidirectional causal relationship between peripheral immune cell counts and the risk of PCa.ResultsThe primary analysis using the IVW method suggests a potential causal association between basophil counts and the risk of prostate cancer (PCa), with an odds ratio (OR) of 1.111 and a 95% confidence interval (CI) of 1.011-1.222 (P = 0.028). Conversely, non-causal associations have been observed between other peripheral immune cell types, such as white blood cells, neutrophils, lymphocytes, eosinophils, or monocytes, and the incidence of PCa (P values > 0.05). Furthermore, although reverse analysis indicated a causal link between PCa and the counts of leukocytes and neutrophils (OR = 1.013; 95% CI = 1.002–1.225; P = 0.018 and OR = 1.013; 95% CI = 1.002–1.025; P = 0.019), no causal association was detected between PCa and basophil count (P value > 0.050).ConclusionThis study suggests a potential bidirectional link between peripheral immune cells and prostate cancer, but inconsistencies in Mendelian Randomization methods mean these findings are preliminary and require further investigation.https://www.frontiersin.org/articles/10.3389/fonc.2024.1374927/fullcausalperipheral immune cellsprostate cancer riskinsightsbidirectional Mendelian randomization |
| spellingShingle | Xiaolu Ren Xiaolu Ren Li Zhang Kehua Wang Fang Li Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization Frontiers in Oncology causal peripheral immune cells prostate cancer risk insights bidirectional Mendelian randomization |
| title | Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization |
| title_full | Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization |
| title_fullStr | Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization |
| title_full_unstemmed | Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization |
| title_short | Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization |
| title_sort | causal association of peripheral immune cell counts with risk of prostate cancer insights from bidirectional mendelian randomization |
| topic | causal peripheral immune cells prostate cancer risk insights bidirectional Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1374927/full |
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