The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection
Soil transmitted helminths (STH) infection is a major health problem in tropical countries such as Indonesia. Albendazole is an effective and widely used anthelmintic agent to treat STH; however, it is not effective towards T. trichiura and its effectiveness varies between populations. Hence, we con...
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Wiley
2019-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/6438497 |
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| author | Saleha Sungkar Kartika Q. Putri Muhammad I. S. Taufik Meutia N. Gozali Pratiwi Sudarmono |
| author_facet | Saleha Sungkar Kartika Q. Putri Muhammad I. S. Taufik Meutia N. Gozali Pratiwi Sudarmono |
| author_sort | Saleha Sungkar |
| collection | DOAJ |
| description | Soil transmitted helminths (STH) infection is a major health problem in tropical countries such as Indonesia. Albendazole is an effective and widely used anthelmintic agent to treat STH; however, it is not effective towards T. trichiura and its effectiveness varies between populations. Hence, we conducted a study to determine the effectiveness of triple dose albendazole in children of Perobatang village, Southwest Sumba, Indonesia. A pre-post study was carried out in Perobatang village on July 2016. Children aged 1-15 years old were enrolled in the study and asked to collect stool samples which were then examined using Kato-Katz method. The children infected with STH were given albendazole 400 mg for three consecutive days. From 246 subjects examined, 192 (78%) were positive for any STH consisting of T. trichiura (64%), A. lumbricoides (60%), and hookworms (10%). After treatment, the prevalence of STH decreased significantly (McNemar test, p<0.001) to 27%, T. trichiura 25%, A. lumbricoides 2%, and hookworm 0%. Cure rate for T. trichiura, A. lumbricoides, and hookworms was 61%, 97%, and 100%, respectively. Significant decrease of eggs per gram of feces was found in all STH (Wilcoxon test, p value <0.001 for A. lumbricoides and T. trichiura, p value = 0.027 for hookworms); egg reduction rate for T. trichiura was 91%, A. lumbricoides was 100%, and hookworms was 100%. In conclusion, triple dose albendazole is effective in controlling STH in children of Perobatang village, Southwest Sumba, Indonesia. |
| format | Article |
| id | doaj-art-2375f6a965f14929a1ba3d9b65d2a062 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-2375f6a965f14929a1ba3d9b65d2a0622025-08-20T03:54:57ZengWileyJournal of Parasitology Research2090-00232090-00312019-01-01201910.1155/2019/64384976438497The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths InfectionSaleha Sungkar0Kartika Q. Putri1Muhammad I. S. Taufik2Meutia N. Gozali3Pratiwi Sudarmono4Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaSoil transmitted helminths (STH) infection is a major health problem in tropical countries such as Indonesia. Albendazole is an effective and widely used anthelmintic agent to treat STH; however, it is not effective towards T. trichiura and its effectiveness varies between populations. Hence, we conducted a study to determine the effectiveness of triple dose albendazole in children of Perobatang village, Southwest Sumba, Indonesia. A pre-post study was carried out in Perobatang village on July 2016. Children aged 1-15 years old were enrolled in the study and asked to collect stool samples which were then examined using Kato-Katz method. The children infected with STH were given albendazole 400 mg for three consecutive days. From 246 subjects examined, 192 (78%) were positive for any STH consisting of T. trichiura (64%), A. lumbricoides (60%), and hookworms (10%). After treatment, the prevalence of STH decreased significantly (McNemar test, p<0.001) to 27%, T. trichiura 25%, A. lumbricoides 2%, and hookworm 0%. Cure rate for T. trichiura, A. lumbricoides, and hookworms was 61%, 97%, and 100%, respectively. Significant decrease of eggs per gram of feces was found in all STH (Wilcoxon test, p value <0.001 for A. lumbricoides and T. trichiura, p value = 0.027 for hookworms); egg reduction rate for T. trichiura was 91%, A. lumbricoides was 100%, and hookworms was 100%. In conclusion, triple dose albendazole is effective in controlling STH in children of Perobatang village, Southwest Sumba, Indonesia.http://dx.doi.org/10.1155/2019/6438497 |
| spellingShingle | Saleha Sungkar Kartika Q. Putri Muhammad I. S. Taufik Meutia N. Gozali Pratiwi Sudarmono The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection Journal of Parasitology Research |
| title | The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection |
| title_full | The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection |
| title_fullStr | The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection |
| title_full_unstemmed | The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection |
| title_short | The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection |
| title_sort | effectiveness of triple dose albendazole in treating soil transmitted helminths infection |
| url | http://dx.doi.org/10.1155/2019/6438497 |
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