The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2

The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2

ObjectiveCirculating regulatory T cells (Tregs) are closely related to immune tolerance and maintenance of immune homeostasis. Perhaps, there is a unique immune cell phenotype for difficult-to-treat rheumatoid arthritis (D2T RA). Low-dose interleukin-2 (IL-2) has been considered for the treatment of...

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Bibliographic Details
Main Authors: Huanhuan Yan, Xiaoyu Zi, Huer Yan, Xiaoying Zhang, Jie Bai, Chong Gao, Xiaofeng Li, Caihong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
difficult-to-treat rheumatoid arthritis
regulatory T cells
T helper 17 cells
low-dose interleukin-2
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1522893/full
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