Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment

Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment

Abstract Small colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms. In this study, phenotypically stable SCV strains are successf...

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Bibliographic Details
Main Authors: Tingwang Shi, Qiong Wu, Zesong Ruan, Zhiyuan Luo, Wenbo Wang, Zhao Guo, Yihong Ma, Xin Wang, Guangyu Chu, Han Lin, Min Ge, Yunfeng Chen
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
drug delivery
metabolic reprogramming
osteomyelitis
small colony variant
β‐Lactam resistance
Online Access:https://doi.org/10.1002/advs.202410781
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