Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization

Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization

Abstract In oxygen-deprived conditions, cells respond by activating adaptive mechanisms to bolster their survival and protect tissue integrity. A key player in this process is the HIF-1α signaling cascade, meticulously regulated by Prolyl Hydroxylase Domain 2 (PHD2), which orchestrates cellular resp...

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Main Authors: Jainabbi Irshad Ahmed Patel, Jagadeesha Poyya, Apeksha Padakannaya, Namrata Manjunath Kurdekar, Ajay Sathayanarayan Khandagale, Chandrashekhar Gajanan Joshi, Santosh R. Kanade, Kapaettu Satyamoorthy
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Ischemia
Hypoxia
HIF-1α signaling
Gut microbiota
Siderophores
Online Access:https://doi.org/10.1038/s41598-024-83730-8
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