Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice
Growth hormone (GH) and gut microbiota are key regulators of metabolism and have been linked to the development and treatment of obesity. Although variations in GH levels are associated with changes in gut microbiota composition, the specific effects of GH on gut microbiota and its role in obesity r...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936824000586 |
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| author | Yu Wang Liyuan Ran Fang Zhang Haolin Li Qianqian Cha Kun Yang Haoan Wang Yingjie Wu Zichao Yu |
| author_facet | Yu Wang Liyuan Ran Fang Zhang Haolin Li Qianqian Cha Kun Yang Haoan Wang Yingjie Wu Zichao Yu |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Growth hormone (GH) and gut microbiota are key regulators of metabolism and have been linked to the development and treatment of obesity. Although variations in GH levels are associated with changes in gut microbiota composition, the specific effects of GH on gut microbiota and its role in obesity remain unclear. This study explored the effects of various GH doses (0.25, 0.75 and 1.5 IU/kg) on adipose tissue mass and gut microbiota in high-fat diet-induced obese mice. Notably, high-dose GH (1.5 IU/kg) significantly reduced the adipose tissue mass. This dose also reversed high-fat diet-induced gut microbiota dysbiosis, restoring microbial diversity and increasing the abundance of beneficial genera such as Ruminococcaceae and Muribaculaceae. Additionally, high-dose GH normalized several obesity-related gut microbiota pathways, including starch and sucrose metabolism, galactose metabolism, and secondary bile acid biosynthesis. GH therapy also improved intestinal barrier function, a key determinant of gut microbial homeostasis. These findings underscore the therapeutic potential of GH in obesity management through its effects on gut microbiota, providing new avenues for obesity interventions. |
| format | Article |
| id | doaj-art-2329a44f3534413bb0c99b001cef7ed8 |
| institution | Kabale University |
| issn | 2589-9368 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj-art-2329a44f3534413bb0c99b001cef7ed82024-12-12T05:22:22ZengElsevierMetabolism Open2589-93682024-12-0124100326Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed miceYu Wang0Liyuan Ran1Fang Zhang2Haolin Li3Qianqian Cha4Kun Yang5Haoan Wang6Yingjie Wu7Zichao Yu8Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, ChinaMetabolism and Disease Research Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, ChinaInstitute for Genome Engineered Animal Models of Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, 116044, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, China; Institute for Genome Engineered Animal Models of Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Liaoning Province Key Lab of Genetically Engineered Animal Models, Dalian Medical University, Dalian, 116044, China; Corresponding author. Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, China.Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, China; Corresponding author.Growth hormone (GH) and gut microbiota are key regulators of metabolism and have been linked to the development and treatment of obesity. Although variations in GH levels are associated with changes in gut microbiota composition, the specific effects of GH on gut microbiota and its role in obesity remain unclear. This study explored the effects of various GH doses (0.25, 0.75 and 1.5 IU/kg) on adipose tissue mass and gut microbiota in high-fat diet-induced obese mice. Notably, high-dose GH (1.5 IU/kg) significantly reduced the adipose tissue mass. This dose also reversed high-fat diet-induced gut microbiota dysbiosis, restoring microbial diversity and increasing the abundance of beneficial genera such as Ruminococcaceae and Muribaculaceae. Additionally, high-dose GH normalized several obesity-related gut microbiota pathways, including starch and sucrose metabolism, galactose metabolism, and secondary bile acid biosynthesis. GH therapy also improved intestinal barrier function, a key determinant of gut microbial homeostasis. These findings underscore the therapeutic potential of GH in obesity management through its effects on gut microbiota, providing new avenues for obesity interventions.http://www.sciencedirect.com/science/article/pii/S2589936824000586Growth hormoneObesityGut microbiota |
| spellingShingle | Yu Wang Liyuan Ran Fang Zhang Haolin Li Qianqian Cha Kun Yang Haoan Wang Yingjie Wu Zichao Yu Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice Metabolism Open Growth hormone Obesity Gut microbiota |
| title | Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice |
| title_full | Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice |
| title_fullStr | Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice |
| title_full_unstemmed | Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice |
| title_short | Growth hormone attenuates obesity and reshapes gut microbiota in high-fat diet-fed mice |
| title_sort | growth hormone attenuates obesity and reshapes gut microbiota in high fat diet fed mice |
| topic | Growth hormone Obesity Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2589936824000586 |
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