Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juice
Introduction: Post-contrast acute kidney injury (PC-AKI) is a serious complication when takingiodine-containing radiopaque agents. The study is aimed at pharmacological correction of PK-AKIwith a functional product obtained from fermented red grape berry juice with a high content of stilbenoids (tra...
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| Language: | English |
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Belgorod National Research University
2024-12-01
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| Series: | Research Results in Pharmacology |
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| Online Access: | https://rrpharmacology.ru/index.php/journal/article/view/546 |
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| author | Olesya V. Shcheblykina Daria A. Kostina Natalia G. Stoyanova Igor A. Efremenko Tatyana V. Avtina |
| author_facet | Olesya V. Shcheblykina Daria A. Kostina Natalia G. Stoyanova Igor A. Efremenko Tatyana V. Avtina |
| author_sort | Olesya V. Shcheblykina |
| collection | DOAJ |
| description | Introduction: Post-contrast acute kidney injury (PC-AKI) is a serious complication when takingiodine-containing radiopaque agents. The study is aimed at pharmacological correction of PK-AKIwith a functional product obtained from fermented red grape berry juice with a high content of stilbenoids (trans-resveratrol and its glycoside polydatin).
Materials and Methods: The study was conducted on 36 male CD1 mice, 8-10 weeks old,weighing 25±3 g. The animals were divided into 3 groups (n=12): a group of intact animals; a group with PC-AKI modeling; and a group with PC-AKI modeling and preliminary intragastricadministration of a functional product in a volume of 0.1 mL/10 g per animal. A morphologicalassessment of kidney changes was performed, as well as a blood test for creatinine, urea, andalbumin.
Results: Preliminary administration of the functional product to mice led to a statisticallysignificant decrease in creatinine and urea concentrations to 43.5±1.6 μmol/L and 34.5±1.4μmol/L, respectively; the glomerular filtration rate increased to 66.2±4.1 µL/min and the urea/albumin ratio decreased to 1.9±0.03, with mortality also decreasing to 8.3%.
Conclusion: The preventive use of a functional product based on fermented red berry juice inan amount of 0.1 mL/kg of animal effectively reduces the severity of post-contrast acute kidneyinjury in a mouse model. |
| format | Article |
| id | doaj-art-2327c5ace915445b925940bea2ffbc02 |
| institution | Kabale University |
| issn | 2658-381X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj-art-2327c5ace915445b925940bea2ffbc022025-01-08T13:05:37ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2024-12-0110461616510.18413/rrpharmacology.10.546Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juiceOlesya V. Shcheblykina0https://orcid.org/0000-0003-0346-9835Daria A. Kostina1https://orcid.org/0000-0002-4505-3988Natalia G. Stoyanova2https://orcid.org/0009-0007-4484-5282Igor A. Efremenko3https://orcid.org/0009-0005-5056-2866Tatyana V. Avtina4https://orcid.org/0000-0003-0509-5996Belgorod State National Research UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityBelgorod State National Research UniversityIntroduction: Post-contrast acute kidney injury (PC-AKI) is a serious complication when takingiodine-containing radiopaque agents. The study is aimed at pharmacological correction of PK-AKIwith a functional product obtained from fermented red grape berry juice with a high content of stilbenoids (trans-resveratrol and its glycoside polydatin). Materials and Methods: The study was conducted on 36 male CD1 mice, 8-10 weeks old,weighing 25±3 g. The animals were divided into 3 groups (n=12): a group of intact animals; a group with PC-AKI modeling; and a group with PC-AKI modeling and preliminary intragastricadministration of a functional product in a volume of 0.1 mL/10 g per animal. A morphologicalassessment of kidney changes was performed, as well as a blood test for creatinine, urea, andalbumin. Results: Preliminary administration of the functional product to mice led to a statisticallysignificant decrease in creatinine and urea concentrations to 43.5±1.6 μmol/L and 34.5±1.4μmol/L, respectively; the glomerular filtration rate increased to 66.2±4.1 µL/min and the urea/albumin ratio decreased to 1.9±0.03, with mortality also decreasing to 8.3%. Conclusion: The preventive use of a functional product based on fermented red berry juice inan amount of 0.1 mL/kg of animal effectively reduces the severity of post-contrast acute kidneyinjury in a mouse model.https://rrpharmacology.ru/index.php/journal/article/view/546resveratrolpolydatinpost-contrast acute kidney injuryradiopaque agent |
| spellingShingle | Olesya V. Shcheblykina Daria A. Kostina Natalia G. Stoyanova Igor A. Efremenko Tatyana V. Avtina Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juice Research Results in Pharmacology resveratrol polydatin post-contrast acute kidney injury radiopaque agent |
| title | Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juice |
| title_full | Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juice |
| title_fullStr | Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juice |
| title_full_unstemmed | Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juice |
| title_short | Pharmacological correction of post-contrast acute kidney injury with a functional product based on fermented grape juice |
| title_sort | pharmacological correction of post contrast acute kidney injury with a functional product based on fermented grape juice |
| topic | resveratrol polydatin post-contrast acute kidney injury radiopaque agent |
| url | https://rrpharmacology.ru/index.php/journal/article/view/546 |
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