Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder
Abstract Patients with major depressive disorder (MDD) and borderline personality disorder (BPD) are reported to have disrupted autobiographical memory (AM). Using functional magnetic resonance imaging we investigated behavioral and neural processing of the recall of emotional (sad and happy) memori...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-81840-x |
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| author | Maria Kulesza Katarzyna Rękawek Paweł Holas Dorota Żołnierczyk-Zreda Marlena Sokół-Szawłowska Anna Poleszczyk Artur Marchewka Marek Wypych |
| author_facet | Maria Kulesza Katarzyna Rękawek Paweł Holas Dorota Żołnierczyk-Zreda Marlena Sokół-Szawłowska Anna Poleszczyk Artur Marchewka Marek Wypych |
| author_sort | Maria Kulesza |
| collection | DOAJ |
| description | Abstract Patients with major depressive disorder (MDD) and borderline personality disorder (BPD) are reported to have disrupted autobiographical memory (AM). Using functional magnetic resonance imaging we investigated behavioral and neural processing of the recall of emotional (sad and happy) memories in 30 MDD, 18 BPD, and 34 healthy control (HC) unmedicated women. The behavioral results showed that the MDD group experienced more sadness than the HC after the sad recall, while BPD participants experienced less happiness than HC after the happy recall. The fMRI results for sad AMs, compared to happy AMs, elicited greater activation in multiple brain regions (i.e., medial prefrontal cortex, posterior cingulate cortex, insula) linked to self-related information, emotional processing, and semantic recollection across all groups. Functional connectivity analysis revealed a significant main effect of group between the occipital cortex and precuneus and between occipital cortex and posterior cingulate cortex. The effect was driven by stronger connectivity between the occipital cortex and precuneus in the clinical groups taken together than in the HC. Our results suggest a need for stronger coordination between visual imagery and contextual recall for vivid memory retrieval in these clinical groups. |
| format | Article |
| id | doaj-art-22f4e8b9cb74481d8d9ce5074900653d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-22f4e8b9cb74481d8d9ce5074900653d2024-12-29T12:16:41ZengNature PortfolioScientific Reports2045-23222024-12-0114111710.1038/s41598-024-81840-xNeural processing of sad and happy autobiographical memories in women with depression and borderline personality disorderMaria Kulesza0Katarzyna Rękawek1Paweł Holas2Dorota Żołnierczyk-Zreda3Marlena Sokół-Szawłowska4Anna Poleszczyk5Artur Marchewka6Marek Wypych7Laboratory of Brain Imaging, Nencki Institute of Experimental BiologyLaboratory of Brain Imaging, Nencki Institute of Experimental BiologyFaculty of Psychology, University of WarsawLaboratory of Psychology and Sociology, Central Institute for Labour Protection – National Research InstituteOutpatient Clinic, Institute of Psychiatry and NeurologyDepartment of Clinical Neurophysiology, Institute of Psychiatry and NeurologyLaboratory of Brain Imaging, Nencki Institute of Experimental BiologyLaboratory of Brain Imaging, Nencki Institute of Experimental BiologyAbstract Patients with major depressive disorder (MDD) and borderline personality disorder (BPD) are reported to have disrupted autobiographical memory (AM). Using functional magnetic resonance imaging we investigated behavioral and neural processing of the recall of emotional (sad and happy) memories in 30 MDD, 18 BPD, and 34 healthy control (HC) unmedicated women. The behavioral results showed that the MDD group experienced more sadness than the HC after the sad recall, while BPD participants experienced less happiness than HC after the happy recall. The fMRI results for sad AMs, compared to happy AMs, elicited greater activation in multiple brain regions (i.e., medial prefrontal cortex, posterior cingulate cortex, insula) linked to self-related information, emotional processing, and semantic recollection across all groups. Functional connectivity analysis revealed a significant main effect of group between the occipital cortex and precuneus and between occipital cortex and posterior cingulate cortex. The effect was driven by stronger connectivity between the occipital cortex and precuneus in the clinical groups taken together than in the HC. Our results suggest a need for stronger coordination between visual imagery and contextual recall for vivid memory retrieval in these clinical groups.https://doi.org/10.1038/s41598-024-81840-x |
| spellingShingle | Maria Kulesza Katarzyna Rękawek Paweł Holas Dorota Żołnierczyk-Zreda Marlena Sokół-Szawłowska Anna Poleszczyk Artur Marchewka Marek Wypych Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder Scientific Reports |
| title | Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder |
| title_full | Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder |
| title_fullStr | Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder |
| title_full_unstemmed | Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder |
| title_short | Neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder |
| title_sort | neural processing of sad and happy autobiographical memories in women with depression and borderline personality disorder |
| url | https://doi.org/10.1038/s41598-024-81840-x |
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