Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway

Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway

IntroductionThis study investigates the potential of Bifidobacterium breve BB05 (BB05) in mitigating depressive symptoms in a mouse model of Chronic Unpredictable Mild Stress (CUMS), with fluoxetine as a positive control.Methods and ResultsHigh-dose BB05 (1.0 × 109 CFU/kg, BB05H) significantly reduc...

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Bibliographic Details
Main Authors: Yanni Pan, Qingling Huang, Yuan Liang, Yuwuqi Xie, Fang Tan, Xingyao Long
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Nutrition
Subjects:
Bifidobacterium breve
depressive symptoms
probiotics
chronic unpredictable mild stress
AKT/mTOR pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1529566/full
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