Muramyl dipeptide potentiates Staphylococcus aureus lipoteichoic acid-induced nitric oxide production via TLR2/NOD2/PAFR signaling pathways

Muramyl dipeptide potentiates Staphylococcus aureus lipoteichoic acid-induced nitric oxide production via TLR2/NOD2/PAFR signaling pathways

Lipoteichoic acid (LTA) and peptidoglycan (PGN) are considered as key virulence factors of Staphylococcus aureus, which is a representative sepsis-causing Gram-positive pathogen. However, cooperative effect of S. aureus LTA and PGN on nitric oxide (NO) production is still unclear despite the pivotal...

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Bibliographic Details
Main Authors: Jintaek Im, Jun Ho Jeon, Dongwook Lee, Jeong Woo Park, Woohyung Jun, Suwon Lim, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
Staphylococcus aureus
nitric oxide
lipoteichoic acid
muramyl dipeptide
peptidoglycan
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1451315/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1451315/full

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