Generation of a MYH6 (c.4034T > C) mutant human embryonic stem cell line via CRISPR base editing

Generation of a MYH6 (c.4034T > C) mutant human embryonic stem cell line via CRISPR base editing

The MYH6 gene encodes α-myosin heavy chain in the adult human heart. MYH6 c.4034T > C (p.Leu1345Pro) mutation in MYH6 gene have been reported in patients with hypertrophic cardiomyopathy (HCM), but its causal role in HCM is less certain and has not been established unambiguously. Here, we generat...

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Bibliographic Details
Main Authors: Xiaodong Jiang, Qiying Liu, Lihui Yang, Xiaohong Zhang, Jiaqi Gao, Youxu Jiang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506124003088
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