Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis
Hypertrophic scars (HS) are a fibrotic proliferative disorder that results from an abnormal wound healing process, presenting significant challenges for clinical intervention. The primary characteristics of HS include excessive collagen deposition and angiogenesis. In recent years, the study of mese...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-08-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2025-1249 |
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| author | Sun Junchao Zhao Yujie Qu Zhoujiang Sun Shudong Wang Kun |
| author_facet | Sun Junchao Zhao Yujie Qu Zhoujiang Sun Shudong Wang Kun |
| author_sort | Sun Junchao |
| collection | DOAJ |
| description | Hypertrophic scars (HS) are a fibrotic proliferative disorder that results from an abnormal wound healing process, presenting significant challenges for clinical intervention. The primary characteristics of HS include excessive collagen deposition and angiogenesis. In recent years, the study of mesenchymal stem cells (MSCs) and their derived exosomes has emerged as a prominent area of research within the academic community. However, the therapeutic application of MSCs is impeded by several challenges, including immune rejection, sourcing limitations, ethical dilemmas, and difficulties related to the scalability of exosome production. Cell-free adipose extract (CEFAE), a novel bioproduct derived from adipose tissue, is rich in various active protein factors that are essential for MSCs and their exosomes. CEFAE presents several advantages, including low immunogenicity, non-tumorigenicity, and a high degree of clinical safety. However, the application of CEFAE in the prevention and treatment of scar formation has not been adequately validated through experimental studies. |
| format | Article |
| id | doaj-art-22dabbbea6dc42f6a5c0912a4fcf7cf5 |
| institution | Kabale University |
| issn | 2391-5463 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj-art-22dabbbea6dc42f6a5c0912a4fcf7cf52025-08-25T06:10:52ZengDe GruyterOpen Medicine2391-54632025-08-012019811110.1515/med-2025-1249Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesisSun Junchao0Zhao Yujie1Qu Zhoujiang2Sun Shudong3Wang Kun4School of Clinical Medicine, Shandong Second Medical University, Weifang, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, ChinaDepartment of Burns and Wound Repair, Weifang People’s Hospital, Shandong Second Medical University, Weifang, ChinaDepartment of Burns and Wound Repair, Weifang People’s Hospital, Shandong Second Medical University, Weifang, ChinaHypertrophic scars (HS) are a fibrotic proliferative disorder that results from an abnormal wound healing process, presenting significant challenges for clinical intervention. The primary characteristics of HS include excessive collagen deposition and angiogenesis. In recent years, the study of mesenchymal stem cells (MSCs) and their derived exosomes has emerged as a prominent area of research within the academic community. However, the therapeutic application of MSCs is impeded by several challenges, including immune rejection, sourcing limitations, ethical dilemmas, and difficulties related to the scalability of exosome production. Cell-free adipose extract (CEFAE), a novel bioproduct derived from adipose tissue, is rich in various active protein factors that are essential for MSCs and their exosomes. CEFAE presents several advantages, including low immunogenicity, non-tumorigenicity, and a high degree of clinical safety. However, the application of CEFAE in the prevention and treatment of scar formation has not been adequately validated through experimental studies.https://doi.org/10.1515/med-2025-1249hypertrophic scarcell-free adipose extractcefaecollagenangiogenesisantiangiogenesis |
| spellingShingle | Sun Junchao Zhao Yujie Qu Zhoujiang Sun Shudong Wang Kun Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis Open Medicine hypertrophic scar cell-free adipose extract cefae collagen angiogenesis antiangiogenesis |
| title | Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis |
| title_full | Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis |
| title_fullStr | Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis |
| title_full_unstemmed | Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis |
| title_short | Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis |
| title_sort | cell free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis |
| topic | hypertrophic scar cell-free adipose extract cefae collagen angiogenesis antiangiogenesis |
| url | https://doi.org/10.1515/med-2025-1249 |
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