Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines
<b>Aim:</b> In this study on guinea pigs, the relationships between neutralizing antibody titers produced by the addition of powder of Horse Chestnut seed and powder of Mistletoe dried leaves to the vaccines against Foot- and- Mouth Disease (FMD) were investigated and Quasi-Least Squares...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1366 |
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| author | Erdoğan Asar Can Çokçalışkan Tunçer Türkoğlu |
| author_facet | Erdoğan Asar Can Çokçalışkan Tunçer Türkoğlu |
| author_sort | Erdoğan Asar |
| collection | DOAJ |
| description | <b>Aim:</b> In this study on guinea pigs, the relationships between neutralizing antibody
titers produced by the addition of powder of Horse Chestnut seed and
powder of Mistletoe dried leaves to the vaccines against Foot- and- Mouth
Disease (FMD) were investigated and Quasi-Least Squares Regression (QLS)
method in data analysis was introduced for the veterinary vaccine studies.<p>
<b>Materials and Methods:</b> The experimental FMD vaccines were administered
to three groups by subcutaneous route. Whether the neutralizing antibody titer
levels (NATL) in the three groups were different according to the homologuos
virus neutralization test (VNT) was statistically analyzed. Blood samples
were taken from the animals to measure NATL generated in animals as a result
of vaccination. These blood samples were taken under general anaesthesia, six
times after vaccination (7, 14, 28, 60, 120 and 270 days), NATL measurements
were made. Analyzes on the longitudinal data obtained were performed with
QLS and Generalized Estimation Equations (GEE) methods.<p>
<b>Results:</b> It was observed that the measurement times (days) in NATL variable
(response variable) was not significant in both QLS and GEE methods (p
>0.05). Similarly, the group effect was not found to be significant in both methods
(p> 0.05).<p>
<b>Conclusion:</b> The fact that the group variable effect on NATL variable was not
found to be statistically significant means that the effects of the addition of
powder of Horse Chestnut seed and Mistletoe dried leaves to the FMD vaccines
on the groups were not different. |
| format | Article |
| id | doaj-art-22afa5cd824641a5b441c8c81f1d10b8 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-22afa5cd824641a5b441c8c81f1d10b82025-01-02T22:36:19ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19533732092161366Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccinesErdoğan Asar0Can Çokçalışkan1Tunçer Türkoğlu2Turkish Statistical Institute, Statistical Consultancy, Ankara, TurkeyMinistry of Agriculture and Forestry, Institute of Foot and Mouth Disease, Ankara, TurkeyMinistry of Agriculture and Forestry, Institute of Foot and Mouth Disease, Ankara, Turkey<b>Aim:</b> In this study on guinea pigs, the relationships between neutralizing antibody titers produced by the addition of powder of Horse Chestnut seed and powder of Mistletoe dried leaves to the vaccines against Foot- and- Mouth Disease (FMD) were investigated and Quasi-Least Squares Regression (QLS) method in data analysis was introduced for the veterinary vaccine studies.<p> <b>Materials and Methods:</b> The experimental FMD vaccines were administered to three groups by subcutaneous route. Whether the neutralizing antibody titer levels (NATL) in the three groups were different according to the homologuos virus neutralization test (VNT) was statistically analyzed. Blood samples were taken from the animals to measure NATL generated in animals as a result of vaccination. These blood samples were taken under general anaesthesia, six times after vaccination (7, 14, 28, 60, 120 and 270 days), NATL measurements were made. Analyzes on the longitudinal data obtained were performed with QLS and Generalized Estimation Equations (GEE) methods.<p> <b>Results:</b> It was observed that the measurement times (days) in NATL variable (response variable) was not significant in both QLS and GEE methods (p >0.05). Similarly, the group effect was not found to be significant in both methods (p> 0.05).<p> <b>Conclusion:</b> The fact that the group variable effect on NATL variable was not found to be statistically significant means that the effects of the addition of powder of Horse Chestnut seed and Mistletoe dried leaves to the FMD vaccines on the groups were not different.http://eurasianjvetsci.org/pdf.php3?id=1366foot-and-mouth diseasevaccineviscum albumaesculus hippocastanumquasi-least squares regression |
| spellingShingle | Erdoğan Asar Can Çokçalışkan Tunçer Türkoğlu Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines Eurasian Journal of Veterinary Sciences foot-and-mouth disease vaccine viscum album aesculus hippocastanum quasi-least squares regression |
| title | Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines |
| title_full | Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines |
| title_fullStr | Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines |
| title_full_unstemmed | Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines |
| title_short | Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines |
| title_sort | investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines |
| topic | foot-and-mouth disease vaccine viscum album aesculus hippocastanum quasi-least squares regression |
| url | http://eurasianjvetsci.org/pdf.php3?id=1366 |
| work_keys_str_mv | AT erdoganasar investigationofadjuvanteffectofviscumalbumandaesculushippocastanuminfmdvaccines AT cancokcalıskan investigationofadjuvanteffectofviscumalbumandaesculushippocastanuminfmdvaccines AT tuncerturkoglu investigationofadjuvanteffectofviscumalbumandaesculushippocastanuminfmdvaccines |