Investigation of adjuvant effect of viscum album and aesculus hippocastanum in fmd vaccines
<b>Aim:</b> In this study on guinea pigs, the relationships between neutralizing antibody titers produced by the addition of powder of Horse Chestnut seed and powder of Mistletoe dried leaves to the vaccines against Foot- and- Mouth Disease (FMD) were investigated and Quasi-Least Squares...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1366 |
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| Summary: | <b>Aim:</b> In this study on guinea pigs, the relationships between neutralizing antibody
titers produced by the addition of powder of Horse Chestnut seed and
powder of Mistletoe dried leaves to the vaccines against Foot- and- Mouth
Disease (FMD) were investigated and Quasi-Least Squares Regression (QLS)
method in data analysis was introduced for the veterinary vaccine studies.<p>
<b>Materials and Methods:</b> The experimental FMD vaccines were administered
to three groups by subcutaneous route. Whether the neutralizing antibody titer
levels (NATL) in the three groups were different according to the homologuos
virus neutralization test (VNT) was statistically analyzed. Blood samples
were taken from the animals to measure NATL generated in animals as a result
of vaccination. These blood samples were taken under general anaesthesia, six
times after vaccination (7, 14, 28, 60, 120 and 270 days), NATL measurements
were made. Analyzes on the longitudinal data obtained were performed with
QLS and Generalized Estimation Equations (GEE) methods.<p>
<b>Results:</b> It was observed that the measurement times (days) in NATL variable
(response variable) was not significant in both QLS and GEE methods (p
>0.05). Similarly, the group effect was not found to be significant in both methods
(p> 0.05).<p>
<b>Conclusion:</b> The fact that the group variable effect on NATL variable was not
found to be statistically significant means that the effects of the addition of
powder of Horse Chestnut seed and Mistletoe dried leaves to the FMD vaccines
on the groups were not different. |
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| ISSN: | 1309-6958 2146-1953 |