Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Abstract Ferroptosis, a form of iron‐dependent cell death, plays a pivotal role in age‐related diseases; yet, its impact on cellular senescence and healthspan in mammals remains largely unexplored. This study identifies ferroptosis as a key regulator of cellular senescence, showing that its inhibiti...

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Main Authors: Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
cellular senescence
ferroptosis
ferrostatin‐1
glutathione peroxidase 4
healthspan
Online Access:https://doi.org/10.1002/advs.202416559
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