Recurrent design patterns in the feedback regulation of the mammalian signalling network

Abstract Biochemical networks are characterized by recurrent patterns and motifs, but the design principles underlying the dynamics of the mammalian intracellular signalling network remain unclear. We systematically analysed decay rates of 134 signalling proteins and investigated their gene expressi...

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Bibliographic Details
Main Authors: Stefan Legewie, Hanspeter Herzel, Hans V Westerhoff, Nils Blüthgen
Format: Article
Language:English
Published: Springer Nature 2008-05-01
Series:Molecular Systems Biology
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Online Access:https://doi.org/10.1038/msb.2008.29
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