Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives

Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives

Abstract RNA pseudouridylation, a dynamic and reversible post‐transcriptional modification found in diverse RNA species, is crucial for various biological processes, including tRNA homeostasis, tRNA transport, translation initiation regulation, pre‐mRNA splicing, enhancement of mRNA translation, and...

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Main Authors: Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Clinical and Translational Medicine
Subjects:
cancer
disease
post‐transcriptional modification
pseudouridylation
Online Access:https://doi.org/10.1002/ctm2.70190
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