Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patients
Objective Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of lymphoma. Circulating cell-free DNA (cfDNA) is the promising liquid biopsy in malignancy.Method Assessment of cfDNA concentration and DNA integrity index (DII) in 30 newly diagnosed DLBCL patients and correlating them with the...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Alexandria Journal of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20905068.2024.2368693 |
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| author | Wessal Elbordiny Akram Abdel Moneim Deghady Amr Abdel Aziz Elsayed Ahmed Abdelrahman Shehata Nermeen Ahmed Mohamed Eldabah |
| author_facet | Wessal Elbordiny Akram Abdel Moneim Deghady Amr Abdel Aziz Elsayed Ahmed Abdelrahman Shehata Nermeen Ahmed Mohamed Eldabah |
| author_sort | Wessal Elbordiny |
| collection | DOAJ |
| description | Objective Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of lymphoma. Circulating cell-free DNA (cfDNA) is the promising liquid biopsy in malignancy.Method Assessment of cfDNA concentration and DNA integrity index (DII) in 30 newly diagnosed DLBCL patients and correlating them with the international prognostic index.Results Circulating cfDNA concentration was significantly higher in newly diagnosed DLBCL patients than controls, while DII was significantly lower. There was a significant correlation between cfDNA concentration and adverse prognostic factors.Conclusion cfDNA concentration is potentially strong diagnostic and prognostic marker of DLBCL, however DII is only useful as a diagnostic biomarker. |
| format | Article |
| id | doaj-art-21e2ee8d7de94882bfa42e88f4b683e2 |
| institution | Kabale University |
| issn | 2090-5068 2090-5076 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Alexandria Journal of Medicine |
| spelling | doaj-art-21e2ee8d7de94882bfa42e88f4b683e22024-11-22T08:38:07ZengTaylor & Francis GroupAlexandria Journal of Medicine2090-50682090-50762024-12-0160120821410.1080/20905068.2024.2368693Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patientsWessal Elbordiny0Akram Abdel Moneim Deghady1Amr Abdel Aziz Elsayed2Ahmed Abdelrahman Shehata3Nermeen Ahmed Mohamed Eldabah4Department of Clinical and Chemical Pathology, Alexandria University, Alexandria, EgyptDepartment of Clinical and Chemical Pathology, Alexandria University, Alexandria, EgyptDepartment of Clinical Oncology and Nuclear Medicine, Alexandria University, Alexandria, EgyptDepartment of Hematology, Alexandria University, Alexandria, EgyptDepartment of Clinical and Chemical Pathology, Alexandria University, Alexandria, EgyptObjective Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of lymphoma. Circulating cell-free DNA (cfDNA) is the promising liquid biopsy in malignancy.Method Assessment of cfDNA concentration and DNA integrity index (DII) in 30 newly diagnosed DLBCL patients and correlating them with the international prognostic index.Results Circulating cfDNA concentration was significantly higher in newly diagnosed DLBCL patients than controls, while DII was significantly lower. There was a significant correlation between cfDNA concentration and adverse prognostic factors.Conclusion cfDNA concentration is potentially strong diagnostic and prognostic marker of DLBCL, however DII is only useful as a diagnostic biomarker.https://www.tandfonline.com/doi/10.1080/20905068.2024.2368693Cell free DNAlymphomabiopsybiomarkerprognosis |
| spellingShingle | Wessal Elbordiny Akram Abdel Moneim Deghady Amr Abdel Aziz Elsayed Ahmed Abdelrahman Shehata Nermeen Ahmed Mohamed Eldabah Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patients Alexandria Journal of Medicine Cell free DNA lymphoma biopsy biomarker prognosis |
| title | Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patients |
| title_full | Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patients |
| title_fullStr | Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patients |
| title_full_unstemmed | Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patients |
| title_short | Assessment of circulating free DNA as a non-invasive biomarker for diffuse large B-cell lymphoma in Egyptian patients |
| title_sort | assessment of circulating free dna as a non invasive biomarker for diffuse large b cell lymphoma in egyptian patients |
| topic | Cell free DNA lymphoma biopsy biomarker prognosis |
| url | https://www.tandfonline.com/doi/10.1080/20905068.2024.2368693 |
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