Functional ultrasound and brain connectivity reveal central nervous system compromise in Trembler-J mice model of Charcot-Marie-Tooth disease

Functional ultrasound and brain connectivity reveal central nervous system compromise in Trembler-J mice model of Charcot-Marie-Tooth disease

Abstract The Charcot-Marie-Tooth-1E (CMT1E) disease is typically described as a peripheral neuropathy in humans, causing decreased nerve conduction, spastic paralysis, and tremor. The Trembler-J (TrJ) mice serve as a high fidelity model of this disease. Here, we use functional ultrasound (fUS) and f...

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Main Authors: Maximiliano Anzibar Fialho, Mariana Martínez Barreiro, Lucia Vázquez Alberdi, Juan Pablo Damián, Maria Vittoria Di Tomaso, Jérôme Baranger, Mickael Tanter, Miguel Calero, Carlos Negreira, Nicolás Rubido, Alejandra Kun, Javier Brum
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-80022-z
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