The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients.
<h4>Objective</h4>Tardive dyskinesia (TD) is a human hyperkinetic movement disorder as a result of potentially irreversible long-term chronic first-generation antipsychotic medications. Unfortunately, mechanisms involved in the development of TD have been poorly understood. Previous stud...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070963&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331800372936704 |
|---|---|
| author | Hongqiang Sun Fan Wang Hongzhen Fan Quanzhi Yan Kaiyan Cui Wei Yuan Fushuai Zhao Lili Zhao Jie Yuan Fude Yang Thomas R Kosten Xiang Yang Zhang |
| author_facet | Hongqiang Sun Fan Wang Hongzhen Fan Quanzhi Yan Kaiyan Cui Wei Yuan Fushuai Zhao Lili Zhao Jie Yuan Fude Yang Thomas R Kosten Xiang Yang Zhang |
| author_sort | Hongqiang Sun |
| collection | DOAJ |
| description | <h4>Objective</h4>Tardive dyskinesia (TD) is a human hyperkinetic movement disorder as a result of potentially irreversible long-term chronic first-generation antipsychotic medications. Unfortunately, mechanisms involved in the development of TD have been poorly understood. Previous studies have indicated that some genetic polymorphisms of immune system and dopamine beta-hydroxylase (DBH) genes may be involved in the pathogenesis of TD. Rs1800872 and rs72393728 are located on the promoter of interleukin-10 (IL10) and DBH gene, respectively. The genetic association between the rs1800872 and TD is unclear. Previous studies have indicated that genetic variations of IL 10 and DBH are implicated in the positive and negative symptoms in schizophrenia. However, the interaction of two variations with severity of TD and symptoms of schizophrenic patients with TD has not been reported. The present study investigated whether these variations and their interaction were associated with clinical phenotypes of TD with schizophrenia in a genetically homogeneous northern Chinese Han population.<h4>Methods</h4>Rs1800872 and rs72393728 were genotyped in schizophrenic patients with TD (n = 372) and without TD (NTD; n = 412). The Abnormal Involuntary Movement Scale (AIMS) and Positive and Negative Syndrome Scale (PANSS) were applied to assess the severity of TD and psychopathology of schizophrenia, respectively.<h4>Results</h4>The allele and genotype frequencies of rs1800872 and rs72393728 did not significantly differ between TD and NTD patients (p>0.05). No significant difference was found in the AIMS total score among the genotypes of two loci (p>0.05). Interestingly, the interaction of rs1800872 and rs72393728 showed a significant association with the PANSS general score (p = 0.011), and a trend toward to the PANSS total score (p = 0.055).<h4>Conclusion</h4>These findings suggest that the interaction of rs1800872 and rs72393728 variants may play a role in psychopathology of the general symptoms on PANSS in schizophrenic patients with TD in a northern Chinese Han population. |
| format | Article |
| id | doaj-art-21c17a968db8476fa6d74ff53c1b3c1d |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-21c17a968db8476fa6d74ff53c1b3c1d2025-08-20T03:46:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7096310.1371/journal.pone.0070963The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients.Hongqiang SunFan WangHongzhen FanQuanzhi YanKaiyan CuiWei YuanFushuai ZhaoLili ZhaoJie YuanFude YangThomas R KostenXiang Yang Zhang<h4>Objective</h4>Tardive dyskinesia (TD) is a human hyperkinetic movement disorder as a result of potentially irreversible long-term chronic first-generation antipsychotic medications. Unfortunately, mechanisms involved in the development of TD have been poorly understood. Previous studies have indicated that some genetic polymorphisms of immune system and dopamine beta-hydroxylase (DBH) genes may be involved in the pathogenesis of TD. Rs1800872 and rs72393728 are located on the promoter of interleukin-10 (IL10) and DBH gene, respectively. The genetic association between the rs1800872 and TD is unclear. Previous studies have indicated that genetic variations of IL 10 and DBH are implicated in the positive and negative symptoms in schizophrenia. However, the interaction of two variations with severity of TD and symptoms of schizophrenic patients with TD has not been reported. The present study investigated whether these variations and their interaction were associated with clinical phenotypes of TD with schizophrenia in a genetically homogeneous northern Chinese Han population.<h4>Methods</h4>Rs1800872 and rs72393728 were genotyped in schizophrenic patients with TD (n = 372) and without TD (NTD; n = 412). The Abnormal Involuntary Movement Scale (AIMS) and Positive and Negative Syndrome Scale (PANSS) were applied to assess the severity of TD and psychopathology of schizophrenia, respectively.<h4>Results</h4>The allele and genotype frequencies of rs1800872 and rs72393728 did not significantly differ between TD and NTD patients (p>0.05). No significant difference was found in the AIMS total score among the genotypes of two loci (p>0.05). Interestingly, the interaction of rs1800872 and rs72393728 showed a significant association with the PANSS general score (p = 0.011), and a trend toward to the PANSS total score (p = 0.055).<h4>Conclusion</h4>These findings suggest that the interaction of rs1800872 and rs72393728 variants may play a role in psychopathology of the general symptoms on PANSS in schizophrenic patients with TD in a northern Chinese Han population.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070963&type=printable |
| spellingShingle | Hongqiang Sun Fan Wang Hongzhen Fan Quanzhi Yan Kaiyan Cui Wei Yuan Fushuai Zhao Lili Zhao Jie Yuan Fude Yang Thomas R Kosten Xiang Yang Zhang The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients. PLoS ONE |
| title | The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients. |
| title_full | The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients. |
| title_fullStr | The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients. |
| title_full_unstemmed | The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients. |
| title_short | The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients. |
| title_sort | interaction of polymorphisms of il10 and dbh was associated with general symptoms of panss with td in chinese han schizophrenic patients |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070963&type=printable |
| work_keys_str_mv | AT hongqiangsun theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT fanwang theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT hongzhenfan theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT quanzhiyan theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT kaiyancui theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT weiyuan theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT fushuaizhao theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT lilizhao theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT jieyuan theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT fudeyang theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT thomasrkosten theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT xiangyangzhang theinteractionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT hongqiangsun interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT fanwang interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT hongzhenfan interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT quanzhiyan interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT kaiyancui interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT weiyuan interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT fushuaizhao interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT lilizhao interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT jieyuan interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT fudeyang interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT thomasrkosten interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients AT xiangyangzhang interactionofpolymorphismsofil10anddbhwasassociatedwithgeneralsymptomsofpansswithtdinchinesehanschizophrenicpatients |