Síndrome de Parkinson e L-dopa Treatment of parkinsonism with L-Dopa
Os autores assinalam o efeito favorável da L-Dopa no tratamento da síndrome parkinsoniana, apresentados por 25 pacientes. Tecem considerações sobre os efeitos colaterais e resultados terapêuticos. Assinalam a presença de eosinofilia após o tratamento em alguns casos e chamam a atenção sobre dois cas...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
1971-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1971000200005 |
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| Summary: | Os autores assinalam o efeito favorável da L-Dopa no tratamento da síndrome parkinsoniana, apresentados por 25 pacientes. Tecem considerações sobre os efeitos colaterais e resultados terapêuticos. Assinalam a presença de eosinofilia após o tratamento em alguns casos e chamam a atenção sobre dois casos que tiveram crises convulsivas durante o tratamento.<br>Encouraged by the recent literature on the subject, the authors decided to treat 18 patients in double-blind fashion using L-Dopa against a placebo during 4 weeks. Dosage was gradually increased from 0,5 g to 4 g within this four-week period. Afterwards the trial proceeded openly, all patients receiving L-Dopa. Further 7 patients were added, making up a total number of 25. The trial was carried on for further 8 weeks. Blood counts, liver function tests, urinalysis, ECG and EEG were performed. Eosinophilia, of which the origin could not be ascertained, was found in 8 cases, and generalised convulsions ocurred in two cases. By the 8th week of treatment 6 patients showed marked improvement; 12 had improved noticeably, and the remaining 7 were slightly better. Hyperkinesia and postural hypotension were controlled by dosage reduction. Four patients reported increase of sexual activity. The trial proceeds, a clinical reappraisal being foreseen for the 12th month of. treatment. |
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| ISSN: | 0004-282X 1678-4227 |