Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus
Background: LPV and MCV emerge as recent additions to the Polyomaviridae family, capable of inducing important infections. Studies have suggested the presence of LPV in human populations, with potential involvement in central nervous system (CNS) diseases. Additionally, MCV, closely related to LPV,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | New Microbes and New Infections |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2052297524002555 |
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| author | Bahman Abedi Kiasari Amir Hossein Alipour Negar Hemmati Mohammad Gholamnezhad Fatemeh Hoda Fallah |
| author_facet | Bahman Abedi Kiasari Amir Hossein Alipour Negar Hemmati Mohammad Gholamnezhad Fatemeh Hoda Fallah |
| author_sort | Bahman Abedi Kiasari |
| collection | DOAJ |
| description | Background: LPV and MCV emerge as recent additions to the Polyomaviridae family, capable of inducing important infections. Studies have suggested the presence of LPV in human populations, with potential involvement in central nervous system (CNS) diseases. Additionally, MCV, closely related to LPV, has been implicated in Merkel cell carcinoma (MCC). This study aimed to explore the prevalence of LPV and MCV in individuals with compromised immunity due to chronic viral infections. Methods: 340 specimens, including HIV PCR-positive, HBV PCR-positive, HCV PCR-positive, and HIV/HBV/HCV negative sera, underwent screening via PCR technique to identify LPV and MCV genomes. Subsequently, sequencing was employed to validate the viral identity. Results: Out of all specimens, MCV DNA was detected in 8.52 % of participants, with a significantly higher prevalence in HIV-positive individuals (26.4 %). LPV was detected in only one HIV-positive patient. No co-detection of MCV and LPV was observed. Phylogenetic analysis confirmed the genetic similarity of the detected MCV strains to known references, while the LPV sequence showed 99 % identity to the published sequences of LPV-K38. Conclusion: This research provides insights into the prevalence of LPV and MCV in individuals with chronic viral infections. The study highlights the potential association between MCV and immunocompromised states, emphasizing the need for comprehensive investigations to understand the epidemiology, transmission routes, and clinical implications of these polyomaviruses in human populations. |
| format | Article |
| id | doaj-art-21b2e89cc57249739bcf6e449110d926 |
| institution | Kabale University |
| issn | 2052-2975 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj-art-21b2e89cc57249739bcf6e449110d9262024-12-13T10:57:14ZengElsevierNew Microbes and New Infections2052-29752024-12-0162101471Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virusBahman Abedi Kiasari0Amir Hossein Alipour1Negar Hemmati2Mohammad Gholamnezhad3Fatemeh Hoda Fallah4Microbiology and Immunology Group, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranMicrobiology and Immunology Group, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Gene Therapy Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranFaculty of Veterinary Medicine, University of Tehran, Tehran, IranClinical Research Development Unit, Yasuj University of Medical Sciences, Yasuj, Iran; Corresponding author. Clinical Research Development Unit, Yasuj University of Medical Sciences, Yasuj, Iran.Allergy and Clinical Immunology Department, Children's Medical Centre, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author. Allergy and Clinical Immunology Department, Children's Medical Centre, Tehran University of Medical Sciences, Tehran, Iran.Background: LPV and MCV emerge as recent additions to the Polyomaviridae family, capable of inducing important infections. Studies have suggested the presence of LPV in human populations, with potential involvement in central nervous system (CNS) diseases. Additionally, MCV, closely related to LPV, has been implicated in Merkel cell carcinoma (MCC). This study aimed to explore the prevalence of LPV and MCV in individuals with compromised immunity due to chronic viral infections. Methods: 340 specimens, including HIV PCR-positive, HBV PCR-positive, HCV PCR-positive, and HIV/HBV/HCV negative sera, underwent screening via PCR technique to identify LPV and MCV genomes. Subsequently, sequencing was employed to validate the viral identity. Results: Out of all specimens, MCV DNA was detected in 8.52 % of participants, with a significantly higher prevalence in HIV-positive individuals (26.4 %). LPV was detected in only one HIV-positive patient. No co-detection of MCV and LPV was observed. Phylogenetic analysis confirmed the genetic similarity of the detected MCV strains to known references, while the LPV sequence showed 99 % identity to the published sequences of LPV-K38. Conclusion: This research provides insights into the prevalence of LPV and MCV in individuals with chronic viral infections. The study highlights the potential association between MCV and immunocompromised states, emphasizing the need for comprehensive investigations to understand the epidemiology, transmission routes, and clinical implications of these polyomaviruses in human populations.http://www.sciencedirect.com/science/article/pii/S2052297524002555Lymphotropic polyomavirusMerkel cell polyomavirusChronic viral infectionsCompromised immunity |
| spellingShingle | Bahman Abedi Kiasari Amir Hossein Alipour Negar Hemmati Mohammad Gholamnezhad Fatemeh Hoda Fallah Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus New Microbes and New Infections Lymphotropic polyomavirus Merkel cell polyomavirus Chronic viral infections Compromised immunity |
| title | Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus |
| title_full | Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus |
| title_fullStr | Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus |
| title_full_unstemmed | Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus |
| title_short | Lymphotropic polyomavirus and Merkel cell polyomavirus in patients infected with HIV or hepatitis B or C virus |
| title_sort | lymphotropic polyomavirus and merkel cell polyomavirus in patients infected with hiv or hepatitis b or c virus |
| topic | Lymphotropic polyomavirus Merkel cell polyomavirus Chronic viral infections Compromised immunity |
| url | http://www.sciencedirect.com/science/article/pii/S2052297524002555 |
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