The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease
Purpose: Exercises increase platelet activation and aggregation in patients with cardiovascular diseases especially at high intensities. The aim of the study was to investigate the effect of 8 weeks of high-intensity interval training on platelet activation and aggregation and phosphorylation of VAS...
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Shahid Beheshti University
2019-01-01
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| Series: | فیزیولوژی ورزش و فعالیت بدنی |
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| Online Access: | https://joeppa.sbu.ac.ir/article_98936_c7a85cde67e9916ed7ff850d95095f82.pdf |
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| author | Akbar Nouri-habashi Sajad Ahmadizad Morteza Salimian Hiwa Rahmani |
| author_facet | Akbar Nouri-habashi Sajad Ahmadizad Morteza Salimian Hiwa Rahmani |
| author_sort | Akbar Nouri-habashi |
| collection | DOAJ |
| description | Purpose: Exercises increase platelet activation and aggregation in patients with cardiovascular diseases especially at high intensities. The aim of the study was to investigate the effect of 8 weeks of high-intensity interval training on platelet activation and aggregation and phosphorylation of VASPser239 in the coronary heart patients.Methods: For this purpose, twenty CABG and PCI patients (≤ 3 months) participated voluntarily and were randomly divided into two groups; i.e. control (N=10) and interval training (N=10) groups. Anthropometric characteristics and peak oxygen consumption were recorded a week before the start. High-intensity interval training group patients participated in an 8 weeks exercise training program, three times a week. The interval training program consisted of a warm-up, 8 reps/ four min (exercise: 2min, active recovery: 2min, intensity: 90/ 30) and finally, cool down. Each session lasted 40 min. The training intensity was started 75/ 15% of the peak oxygen consumption but gradually increased during the first two weeks to reach 90/ 30% of peak oxygen consumption in the last two weeks. The control group did not participate in regular exercises during this period. Blood samples were taken before and 48h after the last exercise session and analyzed for platelet aggregation, CD62p expression, and phosphorylation of VASPser239. The dependent and independent t-tests were used for statistical analysis.Results: A significant difference was observed between the two groups in the amount of decrease in platelet aggregation and CD62p expression in response to ADP (P <0.05). Also, the VASP phosphorylation at ser239 was increased significantly in response to NO in the interval training group (P<0.05).Conclusion: Eight weeks of high-intensity interval training led to the improvement in platelet activation and aggregation factors in coronary heart patients of this study. It seems that regular high-intensity exercise may improve platelet function, due to a decrease in CD62P expression and an increase in sensitivity to NO production by endothelial cells. |
| format | Article |
| id | doaj-art-217f81fb6e0e4cdcb5f4e6e51004ab45 |
| institution | Kabale University |
| issn | 2676-3710 2645-4041 |
| language | fas |
| publishDate | 2019-01-01 |
| publisher | Shahid Beheshti University |
| record_format | Article |
| series | فیزیولوژی ورزش و فعالیت بدنی |
| spelling | doaj-art-217f81fb6e0e4cdcb5f4e6e51004ab452024-11-15T04:08:51ZfasShahid Beheshti Universityفیزیولوژی ورزش و فعالیت بدنی2676-37102645-40412019-01-01112496210.48308/joeppa.2019.9893698936The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart diseaseAkbar Nouri-habashi0Sajad Ahmadizad1Morteza Salimian2Hiwa Rahmani3Department of Exercise Physiology and Corrective Exercises, Faculty of Sports Sciences, Urmia University, Urmia, IranDepartment of Sport and Exercise Physiology, Faculty of Sports Sciences, Shahid Beheshti University, Tehran, IranDepartment of Medical Laboratory, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, IranDepartment of Sport and Exercise Physiology, Faculty of Sports Sciences, Shahid Beheshti University, Tehran, IranPurpose: Exercises increase platelet activation and aggregation in patients with cardiovascular diseases especially at high intensities. The aim of the study was to investigate the effect of 8 weeks of high-intensity interval training on platelet activation and aggregation and phosphorylation of VASPser239 in the coronary heart patients.Methods: For this purpose, twenty CABG and PCI patients (≤ 3 months) participated voluntarily and were randomly divided into two groups; i.e. control (N=10) and interval training (N=10) groups. Anthropometric characteristics and peak oxygen consumption were recorded a week before the start. High-intensity interval training group patients participated in an 8 weeks exercise training program, three times a week. The interval training program consisted of a warm-up, 8 reps/ four min (exercise: 2min, active recovery: 2min, intensity: 90/ 30) and finally, cool down. Each session lasted 40 min. The training intensity was started 75/ 15% of the peak oxygen consumption but gradually increased during the first two weeks to reach 90/ 30% of peak oxygen consumption in the last two weeks. The control group did not participate in regular exercises during this period. Blood samples were taken before and 48h after the last exercise session and analyzed for platelet aggregation, CD62p expression, and phosphorylation of VASPser239. The dependent and independent t-tests were used for statistical analysis.Results: A significant difference was observed between the two groups in the amount of decrease in platelet aggregation and CD62p expression in response to ADP (P <0.05). Also, the VASP phosphorylation at ser239 was increased significantly in response to NO in the interval training group (P<0.05).Conclusion: Eight weeks of high-intensity interval training led to the improvement in platelet activation and aggregation factors in coronary heart patients of this study. It seems that regular high-intensity exercise may improve platelet function, due to a decrease in CD62P expression and an increase in sensitivity to NO production by endothelial cells.https://joeppa.sbu.ac.ir/article_98936_c7a85cde67e9916ed7ff850d95095f82.pdfhigh-intensity interval trainingplatelet aggregationp selectinvasp phosphorylation |
| spellingShingle | Akbar Nouri-habashi Sajad Ahmadizad Morteza Salimian Hiwa Rahmani The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease فیزیولوژی ورزش و فعالیت بدنی high-intensity interval training platelet aggregation p selectin vasp phosphorylation |
| title | The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease |
| title_full | The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease |
| title_fullStr | The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease |
| title_full_unstemmed | The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease |
| title_short | The effects of high intensity interval training on platelet aggregation and phosphorylation of VASPser239 in men with coronary heart disease |
| title_sort | effects of high intensity interval training on platelet aggregation and phosphorylation of vaspser239 in men with coronary heart disease |
| topic | high-intensity interval training platelet aggregation p selectin vasp phosphorylation |
| url | https://joeppa.sbu.ac.ir/article_98936_c7a85cde67e9916ed7ff850d95095f82.pdf |
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