Comprehensive phenotypic assessment of nonsense mutations in mitochondrial ND5 in mice

Comprehensive phenotypic assessment of nonsense mutations in mitochondrial ND5 in mice

Abstract Mitochondrial dysfunction induced by mitochondrial DNA (mtDNA) mutations has been implicated in various human diseases. A comprehensive analysis of mitochondrial genetic disorders requires suitable animal models for human disease studies. While gene knockout via premature stop codons is a p...

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Main Authors: Sanghun Kim, Seul Gi Park, Jieun Kim, Seongho Hong, Sang-Mi Cho, Soo-Yeon Lim, Eun-Kyoung Kim, Sungjin Ju, Su Bin Lee, Sol Pin Kim, Tae Young Jeong, Yeji Oh, Seunghun Han, Hae-Rim Kim, Taek Chang Lee, Hyoung-Chin Kim, Won Kee Yoon, Tae Hyeon An, Kyoung-jin Oh, Ki-Hoan Nam, Seonghyun Lee, Kyoungmi Kim, Je Kyung Seong, Hyunji Lee
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01333-9
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https://doi.org/10.1038/s12276-024-01333-9

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