Development and characterization of a low intensity vibrational system for microgravity studies
Abstract Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity r...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-024-00444-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846158294777856000 |
|---|---|
| author | Omor M. Khan Will Gasperini Chess Necessary Zach Jacobs Sam Perry Jason Rexroat Kendall Nelson Paul Gamble Twyman Clements Maximilien DeLeon Sean Howard Anamaria Zavala Mary Farach-Carson Elizabeth Blaber Danielle Wu Aykut Satici Gunes Uzer |
| author_facet | Omor M. Khan Will Gasperini Chess Necessary Zach Jacobs Sam Perry Jason Rexroat Kendall Nelson Paul Gamble Twyman Clements Maximilien DeLeon Sean Howard Anamaria Zavala Mary Farach-Carson Elizabeth Blaber Danielle Wu Aykut Satici Gunes Uzer |
| author_sort | Omor M. Khan |
| collection | DOAJ |
| description | Abstract Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor’s design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions. |
| format | Article |
| id | doaj-art-2136f14666da42ca8fbbf6b6e5c9e7ce |
| institution | Kabale University |
| issn | 2373-8065 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj-art-2136f14666da42ca8fbbf6b6e5c9e7ce2024-11-24T12:37:15ZengNature Portfolionpj Microgravity2373-80652024-11-011011910.1038/s41526-024-00444-xDevelopment and characterization of a low intensity vibrational system for microgravity studiesOmor M. Khan0Will Gasperini1Chess Necessary2Zach Jacobs3Sam Perry4Jason Rexroat5Kendall Nelson6Paul Gamble7Twyman Clements8Maximilien DeLeon9Sean Howard10Anamaria Zavala11Mary Farach-Carson12Elizabeth Blaber13Danielle Wu14Aykut Satici15Gunes Uzer16Department of Mechanical and Biomedical Engineering, Boise State UniversityDepartment of Mechanical and Biomedical Engineering, Boise State UniversitySpace Tango IncSpace Tango IncSpace Tango IncSpace Tango IncSpace Tango IncSpace Tango IncSpace Tango IncDepartment of Bioengineering, Rice UniversityDepartment of Mechanical and Biomedical Engineering, Boise State UniversityDepartment of Mechanical and Biomedical Engineering, Boise State UniversityDepartment of Bioengineering, Rice UniversityCenter for Biotechnology and Rd. Interdisciplinary Studies, Department of Biomedical Engineering, Rensselaer Polytechnic InstituteDepartment of Bioengineering, Rice UniversityDepartment of Mechanical and Biomedical Engineering, Boise State UniversityDepartment of Mechanical and Biomedical Engineering, Boise State UniversityAbstract Extended-duration human spaceflight necessitates a better understanding of the physiological impacts of microgravity. While the ground-based microgravity simulations identified low intensity vibration (LIV) as a possible countermeasure, how cells may respond to LIV under real microgravity remain unexplored. In this way, adaptation of LIV bioreactors for space remains limited, resulting in a significant gap in microgravity research. In this study, we introduce an LIV bioreactor designed specifically for the usage in the International Space Station. Our research covers the bioreactor’s design process and evaluation of the short-term viability of cells encapsulated in hydrogel-laden 3D printed scaffolds under 0.7 g, 90 Hz LIV. An LIV bioreactor compatible with the operation requirements of space missions provides a robust platform to study cellular effects of LIV under real microgravity conditions.https://doi.org/10.1038/s41526-024-00444-x |
| spellingShingle | Omor M. Khan Will Gasperini Chess Necessary Zach Jacobs Sam Perry Jason Rexroat Kendall Nelson Paul Gamble Twyman Clements Maximilien DeLeon Sean Howard Anamaria Zavala Mary Farach-Carson Elizabeth Blaber Danielle Wu Aykut Satici Gunes Uzer Development and characterization of a low intensity vibrational system for microgravity studies npj Microgravity |
| title | Development and characterization of a low intensity vibrational system for microgravity studies |
| title_full | Development and characterization of a low intensity vibrational system for microgravity studies |
| title_fullStr | Development and characterization of a low intensity vibrational system for microgravity studies |
| title_full_unstemmed | Development and characterization of a low intensity vibrational system for microgravity studies |
| title_short | Development and characterization of a low intensity vibrational system for microgravity studies |
| title_sort | development and characterization of a low intensity vibrational system for microgravity studies |
| url | https://doi.org/10.1038/s41526-024-00444-x |
| work_keys_str_mv | AT omormkhan developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT willgasperini developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT chessnecessary developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT zachjacobs developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT samperry developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT jasonrexroat developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT kendallnelson developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT paulgamble developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT twymanclements developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT maximiliendeleon developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT seanhoward developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT anamariazavala developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT maryfarachcarson developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT elizabethblaber developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT daniellewu developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT aykutsatici developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies AT gunesuzer developmentandcharacterizationofalowintensityvibrationalsystemformicrogravitystudies |