Mechanisms and technologies in cancer epigenetics
Cancer’s epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review discusses the intricate mechanisms underlying cancer epigenetics, unraveling the complex interplay between...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1513654/full |
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| author | Zaki A. Sherif Olorunseun O. Ogunwobi Habtom W. Ressom |
| author_facet | Zaki A. Sherif Olorunseun O. Ogunwobi Habtom W. Ressom |
| author_sort | Zaki A. Sherif |
| collection | DOAJ |
| description | Cancer’s epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review discusses the intricate mechanisms underlying cancer epigenetics, unraveling the complex interplay between DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs. We navigate through the tumultuous seas of epigenetic dysregulation, exploring how these processes conspire to silence tumor suppressors and unleash oncogenic potential. The narrative pivots to cutting-edge technologies, revolutionizing our ability to decode the epigenome. From the granular insights of single-cell epigenomics to the holistic view offered by multi-omics approaches, we examine how these tools are reshaping our understanding of tumor heterogeneity and evolution. The review also highlights emerging techniques, such as spatial epigenomics and long-read sequencing, which promise to unveil the hidden dimensions of epigenetic regulation. Finally, we probed the transformative potential of CRISPR-based epigenome editing and computational analysis to transmute raw data into biological insights. This study seeks to synthesize a comprehensive yet nuanced understanding of the contemporary landscape and future directions of cancer epigenetic research. |
| format | Article |
| id | doaj-art-21237bd92ac54bddaee442a0f5548a8c |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-21237bd92ac54bddaee442a0f5548a8c2025-01-07T05:23:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15136541513654Mechanisms and technologies in cancer epigeneticsZaki A. Sherif0Olorunseun O. Ogunwobi1Habtom W. Ressom2Department of Biochemistry & Molecular Biology, Howard University College of Medicine, Washington, DC, United StatesDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, United StatesDepartment of Oncology, Georgetown University Medical Center, Washington, DC, United StatesCancer’s epigenetic landscape, a labyrinthine tapestry of molecular modifications, has long captivated researchers with its profound influence on gene expression and cellular fate. This review discusses the intricate mechanisms underlying cancer epigenetics, unraveling the complex interplay between DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs. We navigate through the tumultuous seas of epigenetic dysregulation, exploring how these processes conspire to silence tumor suppressors and unleash oncogenic potential. The narrative pivots to cutting-edge technologies, revolutionizing our ability to decode the epigenome. From the granular insights of single-cell epigenomics to the holistic view offered by multi-omics approaches, we examine how these tools are reshaping our understanding of tumor heterogeneity and evolution. The review also highlights emerging techniques, such as spatial epigenomics and long-read sequencing, which promise to unveil the hidden dimensions of epigenetic regulation. Finally, we probed the transformative potential of CRISPR-based epigenome editing and computational analysis to transmute raw data into biological insights. This study seeks to synthesize a comprehensive yet nuanced understanding of the contemporary landscape and future directions of cancer epigenetic research.https://www.frontiersin.org/articles/10.3389/fonc.2024.1513654/fullcancerchromatinDNA methylationepigeneticsepigenetic therapyhistone modifications |
| spellingShingle | Zaki A. Sherif Olorunseun O. Ogunwobi Habtom W. Ressom Mechanisms and technologies in cancer epigenetics Frontiers in Oncology cancer chromatin DNA methylation epigenetics epigenetic therapy histone modifications |
| title | Mechanisms and technologies in cancer epigenetics |
| title_full | Mechanisms and technologies in cancer epigenetics |
| title_fullStr | Mechanisms and technologies in cancer epigenetics |
| title_full_unstemmed | Mechanisms and technologies in cancer epigenetics |
| title_short | Mechanisms and technologies in cancer epigenetics |
| title_sort | mechanisms and technologies in cancer epigenetics |
| topic | cancer chromatin DNA methylation epigenetics epigenetic therapy histone modifications |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1513654/full |
| work_keys_str_mv | AT zakiasherif mechanismsandtechnologiesincancerepigenetics AT olorunseunoogunwobi mechanismsandtechnologiesincancerepigenetics AT habtomwressom mechanismsandtechnologiesincancerepigenetics |