Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern Taiwan
Background: The accelerating prevalence of extended-spectrum β-lactamase (ESBL)-producing and multidrug-resistance (MDR) Escherichia coli (E. coli) become a public health challenge worldwide. This study aimed to discuss the prevalence of drug-resistant E. coli colonization and analyze its risk facto...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957223001419 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307437974159360 |
|---|---|
| author | Fang-Chih Lin Wailap Victor Ng Hsiao-Ping Wang Chih-Hsin Hung Jenn-Tzong Chang Chih-Chieh Yang Po-Yen Liu Ming-Fang Cheng |
| author_facet | Fang-Chih Lin Wailap Victor Ng Hsiao-Ping Wang Chih-Hsin Hung Jenn-Tzong Chang Chih-Chieh Yang Po-Yen Liu Ming-Fang Cheng |
| author_sort | Fang-Chih Lin |
| collection | DOAJ |
| description | Background: The accelerating prevalence of extended-spectrum β-lactamase (ESBL)-producing and multidrug-resistance (MDR) Escherichia coli (E. coli) become a public health challenge worldwide. This study aimed to discuss the prevalence of drug-resistant E. coli colonization and analyze its risk factors and clinical characteristics among young infants in Southern Taiwan. Methods: Stool samples were collected from young infants, aged less than three months, within three days of their hospitalization from September to December 2019 in a tertiary hospital. A questionnaire was designed for parents to complete. E. coli colonies were selected and analyzed for antimicrobial susceptibility. PCR-based multilocus sequence typing was to detect the presence of sequence type ST131 and blaCTX-M genes. Results: Among 100 enrolled infants, 36% had fecal carriage of E. coli isolates, of which twenty nine (80.5%) were MDR, thirteen (36.1%) were ESBL-producing isolates and five (13.8%) and ten (27.7%) were ST131 and strains carrying CTX-M-14 gene, respectively. Compared to non-ST131 and non-CTX-M-14 gene carrier, isolates of ST131 and CTX-M-14 gene carrier showed a significantly higher resistance rate to cefixime, ceftriaxone, and gentamycin, with p value all <0.05. Conclusion: The prevalence of ESBL-producing and MDR E. coli fecal carriage were both high in young infants. The most common sequence type is ST131, of which all are strains carrying CTX-M-14. Further surveillance and investigation to control for the high prevalence of antimicrobial-resistant E. coli fecal carriage among infants in Taiwan are warranted. |
| format | Article |
| id | doaj-art-20f6fd8c6fd543f2b16e9aa88ac13a5c |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-20f6fd8c6fd543f2b16e9aa88ac13a5c2025-08-20T03:54:47ZengElsevierPediatrics and Neonatology1875-95722024-03-0165213814410.1016/j.pedneo.2023.04.014Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern TaiwanFang-Chih Lin0Wailap Victor Ng1Hsiao-Ping Wang2Chih-Hsin Hung3Jenn-Tzong Chang4Chih-Chieh Yang5Po-Yen Liu6Ming-Fang Cheng7Division of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDivision of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanInstitute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, TaiwanDivision of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDivision of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; School of Nursing, Fooyin University, Kaohsiung, Taiwan; Corresponding author. No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City 813414, Taiwan (R.O.C.).Background: The accelerating prevalence of extended-spectrum β-lactamase (ESBL)-producing and multidrug-resistance (MDR) Escherichia coli (E. coli) become a public health challenge worldwide. This study aimed to discuss the prevalence of drug-resistant E. coli colonization and analyze its risk factors and clinical characteristics among young infants in Southern Taiwan. Methods: Stool samples were collected from young infants, aged less than three months, within three days of their hospitalization from September to December 2019 in a tertiary hospital. A questionnaire was designed for parents to complete. E. coli colonies were selected and analyzed for antimicrobial susceptibility. PCR-based multilocus sequence typing was to detect the presence of sequence type ST131 and blaCTX-M genes. Results: Among 100 enrolled infants, 36% had fecal carriage of E. coli isolates, of which twenty nine (80.5%) were MDR, thirteen (36.1%) were ESBL-producing isolates and five (13.8%) and ten (27.7%) were ST131 and strains carrying CTX-M-14 gene, respectively. Compared to non-ST131 and non-CTX-M-14 gene carrier, isolates of ST131 and CTX-M-14 gene carrier showed a significantly higher resistance rate to cefixime, ceftriaxone, and gentamycin, with p value all <0.05. Conclusion: The prevalence of ESBL-producing and MDR E. coli fecal carriage were both high in young infants. The most common sequence type is ST131, of which all are strains carrying CTX-M-14. Further surveillance and investigation to control for the high prevalence of antimicrobial-resistant E. coli fecal carriage among infants in Taiwan are warranted.http://www.sciencedirect.com/science/article/pii/S1875957223001419Escherichia coliextended-spectrum β-lactamasemultidrug-resistanceST131young infants |
| spellingShingle | Fang-Chih Lin Wailap Victor Ng Hsiao-Ping Wang Chih-Hsin Hung Jenn-Tzong Chang Chih-Chieh Yang Po-Yen Liu Ming-Fang Cheng Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern Taiwan Pediatrics and Neonatology Escherichia coli extended-spectrum β-lactamase multidrug-resistance ST131 young infants |
| title | Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern Taiwan |
| title_full | Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern Taiwan |
| title_fullStr | Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern Taiwan |
| title_full_unstemmed | Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern Taiwan |
| title_short | Characterization of young infants with fecal carriage of multidrug-resistant Escherichia coli in Southern Taiwan |
| title_sort | characterization of young infants with fecal carriage of multidrug resistant escherichia coli in southern taiwan |
| topic | Escherichia coli extended-spectrum β-lactamase multidrug-resistance ST131 young infants |
| url | http://www.sciencedirect.com/science/article/pii/S1875957223001419 |
| work_keys_str_mv | AT fangchihlin characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan AT wailapvictorng characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan AT hsiaopingwang characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan AT chihhsinhung characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan AT jenntzongchang characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan AT chihchiehyang characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan AT poyenliu characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan AT mingfangcheng characterizationofyounginfantswithfecalcarriageofmultidrugresistantescherichiacoliinsoutherntaiwan |