CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study
Introduction Sarcoidosis is a multisystem disease, predominantly affecting the lungs but can involve the heart, resulting in cardiac sarcoidosis (CS). Patients require MRI/Positron Emission Tomography (PET) scans for diagnosis. Echocardiography, ECG and Holter monitoring may be indicative but not di...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/7/1/e000608.full |
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| author | Ajit Lalvani Katharine Tweed Muhunthan Thillai Lynne Williams Mark Toshner Juan Carlos Quijano-Campos Sharad Agarwal Robert Parker Yi-Da Chiu Kane Dorey Thomas Devine Victoria Stoneman |
| author_facet | Ajit Lalvani Katharine Tweed Muhunthan Thillai Lynne Williams Mark Toshner Juan Carlos Quijano-Campos Sharad Agarwal Robert Parker Yi-Da Chiu Kane Dorey Thomas Devine Victoria Stoneman |
| author_sort | Ajit Lalvani |
| collection | DOAJ |
| description | Introduction Sarcoidosis is a multisystem disease, predominantly affecting the lungs but can involve the heart, resulting in cardiac sarcoidosis (CS). Patients require MRI/Positron Emission Tomography (PET) scans for diagnosis. Echocardiography, ECG and Holter monitoring may be indicative but not diagnostic alone. Patients can present late with conduction defects, heart failure or sudden death. The CASPA (CArdiac Sarcoidosis in PApworth) study protocol aims to (1) use MRI to identify CS prevalence; (2) use speckle-tracking echocardiography, signal averaged ECG and Holter monitoring to look for diagnostic pathways; and (3) identify serum proteins which may be associated with CS.Methods and analysis Participants with pulmonary sarcoidosis (and no known cardiac disease) from Royal Papworth Hospital will have the following: cardiac MRI with late gadolinium, two-dimensional transthoracic echocardiography with speckle tracking, signal averaged ECG and 24-hour Holter monitor. They will provide a serum sample for brain natriuretic peptide levels and proteomics by liquid chromatography coupled to high-resolution mass spectrometry. All data will be collected on OpenClinica platform and analysed approximately 6 months after final patient recruitment.Ethics and dissemination The Camden & Kings Cross Research Ethics Committee approved the protocol (REC number: 17/LO/0667). Integrated Research Approval System (IRAS) 222 720. Dissemination of findings will be via conference presentations and submitted to peer-reviewed journals. |
| format | Article |
| id | doaj-art-20a645ae43d343c98f0524d9f4f4f79c |
| institution | Kabale University |
| issn | 2052-4439 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-20a645ae43d343c98f0524d9f4f4f79c2024-11-24T18:00:08ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392020-09-017110.1136/bmjresp-2020-000608CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort studyAjit Lalvani0Katharine Tweed1Muhunthan Thillai2Lynne Williams3Mark Toshner4Juan Carlos Quijano-Campos5Sharad Agarwal6Robert Parker7Yi-Da Chiu8Kane Dorey9Thomas Devine10Victoria Stoneman11Tuberculosis Research Unit, Imperial College London, London, UKDepartment of Radiology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UKCambridge Interstitial Lung Disease Unit, Royal Papworth Hospital, Cambridge, Cambridgeshire, UKSchool of Healthcare Sciences, Bangor University, Bangor, UKDepartment of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, UKInterstitial Lung Disease Unit, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK2Royal Papworth Hospital, Cambridge, UK1Infinitopes Ltd, Oxford, UKResearch & Development, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UKInterstitial Lung Disease Unit, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UKResearch & Development, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UKRespiratory Support and Sleep Centre, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UKIntroduction Sarcoidosis is a multisystem disease, predominantly affecting the lungs but can involve the heart, resulting in cardiac sarcoidosis (CS). Patients require MRI/Positron Emission Tomography (PET) scans for diagnosis. Echocardiography, ECG and Holter monitoring may be indicative but not diagnostic alone. Patients can present late with conduction defects, heart failure or sudden death. The CASPA (CArdiac Sarcoidosis in PApworth) study protocol aims to (1) use MRI to identify CS prevalence; (2) use speckle-tracking echocardiography, signal averaged ECG and Holter monitoring to look for diagnostic pathways; and (3) identify serum proteins which may be associated with CS.Methods and analysis Participants with pulmonary sarcoidosis (and no known cardiac disease) from Royal Papworth Hospital will have the following: cardiac MRI with late gadolinium, two-dimensional transthoracic echocardiography with speckle tracking, signal averaged ECG and 24-hour Holter monitor. They will provide a serum sample for brain natriuretic peptide levels and proteomics by liquid chromatography coupled to high-resolution mass spectrometry. All data will be collected on OpenClinica platform and analysed approximately 6 months after final patient recruitment.Ethics and dissemination The Camden & Kings Cross Research Ethics Committee approved the protocol (REC number: 17/LO/0667). Integrated Research Approval System (IRAS) 222 720. Dissemination of findings will be via conference presentations and submitted to peer-reviewed journals.https://bmjopenrespres.bmj.com/content/7/1/e000608.full |
| spellingShingle | Ajit Lalvani Katharine Tweed Muhunthan Thillai Lynne Williams Mark Toshner Juan Carlos Quijano-Campos Sharad Agarwal Robert Parker Yi-Da Chiu Kane Dorey Thomas Devine Victoria Stoneman CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study BMJ Open Respiratory Research |
| title | CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study |
| title_full | CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study |
| title_fullStr | CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study |
| title_full_unstemmed | CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study |
| title_short | CASPA (CArdiac Sarcoidosis in PApworth) improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis: protocol for a prospective observational cohort study |
| title_sort | caspa cardiac sarcoidosis in papworth improving the diagnosis of cardiac involvement in patients with pulmonary sarcoidosis protocol for a prospective observational cohort study |
| url | https://bmjopenrespres.bmj.com/content/7/1/e000608.full |
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