Role of eosinophil counts in mediating the association between asthma and colon cancer
Abstract Background Epidemiological findings regarding the association between asthma and the risk of colon cancer (CC) are inconsistent. The causality and potential molecular mechanisms underlying asthma, eosinophil count, and CC remain unknown. Methods We performed Mendelian randomization (MR) ana...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.70012 |
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| author | Zhi‐Qing Zhan Ze‐Min Huang Zhi‐Xin Xie Hao‐Bin Zhou Yu‐Hua Luo Pei‐Zhen Chen Tian‐Ye Luo Baoqing Sun Zhangkai J. Cheng |
| author_facet | Zhi‐Qing Zhan Ze‐Min Huang Zhi‐Xin Xie Hao‐Bin Zhou Yu‐Hua Luo Pei‐Zhen Chen Tian‐Ye Luo Baoqing Sun Zhangkai J. Cheng |
| author_sort | Zhi‐Qing Zhan |
| collection | DOAJ |
| description | Abstract Background Epidemiological findings regarding the association between asthma and the risk of colon cancer (CC) are inconsistent. The causality and potential molecular mechanisms underlying asthma, eosinophil count, and CC remain unknown. Methods We performed Mendelian randomization (MR) analysis to investigate the causality between asthma and CC and attempted to demonstrate that asthma indirectly affects CC mediated by eosinophil count through mediation analysis. Sensitivity analyses and multivariable MR were performed to test the robustness of our findings. Multiple bioinformatics tools were applied to further investigate the underlying mechanisms related to eosinophils that contribute to the pathogenesis of both asthma and CC. Results MR with mediation analyses suggested that eosinophil count may play a role in the mechanism through which asthma reduces the risk of CC. Our bioinformatic analyses identified PPP1R14A as a potential therapeutic target and an eosinophil‐associated biomarker for CC patients. Higher expression of PPP1R14A may be associated with a poorer prognosis in CC patients. Additionally, the lysosome pathway emerges as a shared eosinophil‐related pathway in both asthma and CC. Conclusions Eosinophils may contribute to a lower risk of CC in patients with asthma. PPP1R14A is a potential therapeutic target and biomarker for CC. |
| format | Article |
| id | doaj-art-2098d5dfaba742768e4af3776ef0a2f4 |
| institution | Kabale University |
| issn | 2045-7022 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj-art-2098d5dfaba742768e4af3776ef0a2f42024-12-27T07:32:28ZengWileyClinical and Translational Allergy2045-70222024-12-011412n/an/a10.1002/clt2.70012Role of eosinophil counts in mediating the association between asthma and colon cancerZhi‐Qing Zhan0Ze‐Min Huang1Zhi‐Xin Xie2Hao‐Bin Zhou3Yu‐Hua Luo4Pei‐Zhen Chen5Tian‐Ye Luo6Baoqing Sun7Zhangkai J. Cheng8Department of Clinical Laboratory National Center for Respiratory Medicine National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Medicine Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Medicine Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Medicine Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Medicine Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Medicine Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Medicine Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Laboratory National Center for Respiratory Medicine National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University Guangzhou ChinaDepartment of Clinical Laboratory National Center for Respiratory Medicine National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Medical University Guangzhou ChinaAbstract Background Epidemiological findings regarding the association between asthma and the risk of colon cancer (CC) are inconsistent. The causality and potential molecular mechanisms underlying asthma, eosinophil count, and CC remain unknown. Methods We performed Mendelian randomization (MR) analysis to investigate the causality between asthma and CC and attempted to demonstrate that asthma indirectly affects CC mediated by eosinophil count through mediation analysis. Sensitivity analyses and multivariable MR were performed to test the robustness of our findings. Multiple bioinformatics tools were applied to further investigate the underlying mechanisms related to eosinophils that contribute to the pathogenesis of both asthma and CC. Results MR with mediation analyses suggested that eosinophil count may play a role in the mechanism through which asthma reduces the risk of CC. Our bioinformatic analyses identified PPP1R14A as a potential therapeutic target and an eosinophil‐associated biomarker for CC patients. Higher expression of PPP1R14A may be associated with a poorer prognosis in CC patients. Additionally, the lysosome pathway emerges as a shared eosinophil‐related pathway in both asthma and CC. Conclusions Eosinophils may contribute to a lower risk of CC in patients with asthma. PPP1R14A is a potential therapeutic target and biomarker for CC.https://doi.org/10.1002/clt2.70012asthmacolon cancerimmuneMendelian randomizationPPP1R14A |
| spellingShingle | Zhi‐Qing Zhan Ze‐Min Huang Zhi‐Xin Xie Hao‐Bin Zhou Yu‐Hua Luo Pei‐Zhen Chen Tian‐Ye Luo Baoqing Sun Zhangkai J. Cheng Role of eosinophil counts in mediating the association between asthma and colon cancer Clinical and Translational Allergy asthma colon cancer immune Mendelian randomization PPP1R14A |
| title | Role of eosinophil counts in mediating the association between asthma and colon cancer |
| title_full | Role of eosinophil counts in mediating the association between asthma and colon cancer |
| title_fullStr | Role of eosinophil counts in mediating the association between asthma and colon cancer |
| title_full_unstemmed | Role of eosinophil counts in mediating the association between asthma and colon cancer |
| title_short | Role of eosinophil counts in mediating the association between asthma and colon cancer |
| title_sort | role of eosinophil counts in mediating the association between asthma and colon cancer |
| topic | asthma colon cancer immune Mendelian randomization PPP1R14A |
| url | https://doi.org/10.1002/clt2.70012 |
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