Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study
Background: Patients with primary aldosteronism (PA) exhibit a high prevalence of diabetes mellitus (DM). However, the relationship between visceral adipose tissue (VAT) and new-onset diabetes mellitus (NODM) in PA patients remains unclear. Objectives: To explore the association between VAT and the...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-11-01
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| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/20406223241301892 |
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| author | Wen-Kai Chu Leay Kiaw Er Chin-Chen Chang Jin-Ying Lu Wan-Chen Wu Yao-Chou Tsai Yen-Hung Lin Vin-Cent Wu |
| author_facet | Wen-Kai Chu Leay Kiaw Er Chin-Chen Chang Jin-Ying Lu Wan-Chen Wu Yao-Chou Tsai Yen-Hung Lin Vin-Cent Wu |
| author_sort | Wen-Kai Chu |
| collection | DOAJ |
| description | Background: Patients with primary aldosteronism (PA) exhibit a high prevalence of diabetes mellitus (DM). However, the relationship between visceral adipose tissue (VAT) and new-onset diabetes mellitus (NODM) in PA patients remains unclear. Objectives: To explore the association between VAT and the risk of NODM in PA patients. Design: This is a prospective cohort study spanning 10 years (2010–2020). Methods: A total of 342 PA patients were enrolled prospectively. Abdominal adiposity indexes, including VAT area, VAT ratio, subcutaneous adipose tissue (SAT) area, and SAT ratio, were measured using a computed tomography-based software at diagnosis. Results: Of 342 PA patients (46.2% male, mean age 50.8 ± 11.2 years), 35 (10.2%) developed NODM over a mean follow-up of 7.4 years. A positive nonlinear association between NODM risk and Log (VAT ratio) ⩾ −0.72 was observed (high-VAT group). High VAT (odds ratio (OR), 6.09; p = 0.005), older age (OR, 1.09; p < 0.001), higher body mass index (OR, 1.24; p < 0.001), higher waist-to-hip ratio (OR, 1.11, p < 0.001), lower baseline aldosterone (OR, 0.99, p = 0.011), higher diastolic blood pressure (OR, 1.05, p = 0.012), and lower systolic blood pressure (OR, 0.98, p = 0.045) as risk factors for high VAT. Adrenalectomy did not significantly associate with reduced NODM risk (OR, 0.49; p = 0.292). Conclusion: Our findings highlight that 10.2% of PA patients develop NODM over a mean follow-up of 7.4 years, with high VAT increasing the risk. Baseline VAT is a key determinant of NODM development in PA patients, regardless of targeted treatments. |
| format | Article |
| id | doaj-art-20669f0ead48444c9ad6d282cb772166 |
| institution | Kabale University |
| issn | 2040-6231 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj-art-20669f0ead48444c9ad6d282cb7721662024-12-17T13:03:24ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312024-11-011510.1177/20406223241301892Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort studyWen-Kai ChuLeay Kiaw ErChin-Chen ChangJin-Ying LuWan-Chen WuYao-Chou TsaiYen-Hung LinVin-Cent WuBackground: Patients with primary aldosteronism (PA) exhibit a high prevalence of diabetes mellitus (DM). However, the relationship between visceral adipose tissue (VAT) and new-onset diabetes mellitus (NODM) in PA patients remains unclear. Objectives: To explore the association between VAT and the risk of NODM in PA patients. Design: This is a prospective cohort study spanning 10 years (2010–2020). Methods: A total of 342 PA patients were enrolled prospectively. Abdominal adiposity indexes, including VAT area, VAT ratio, subcutaneous adipose tissue (SAT) area, and SAT ratio, were measured using a computed tomography-based software at diagnosis. Results: Of 342 PA patients (46.2% male, mean age 50.8 ± 11.2 years), 35 (10.2%) developed NODM over a mean follow-up of 7.4 years. A positive nonlinear association between NODM risk and Log (VAT ratio) ⩾ −0.72 was observed (high-VAT group). High VAT (odds ratio (OR), 6.09; p = 0.005), older age (OR, 1.09; p < 0.001), higher body mass index (OR, 1.24; p < 0.001), higher waist-to-hip ratio (OR, 1.11, p < 0.001), lower baseline aldosterone (OR, 0.99, p = 0.011), higher diastolic blood pressure (OR, 1.05, p = 0.012), and lower systolic blood pressure (OR, 0.98, p = 0.045) as risk factors for high VAT. Adrenalectomy did not significantly associate with reduced NODM risk (OR, 0.49; p = 0.292). Conclusion: Our findings highlight that 10.2% of PA patients develop NODM over a mean follow-up of 7.4 years, with high VAT increasing the risk. Baseline VAT is a key determinant of NODM development in PA patients, regardless of targeted treatments.https://doi.org/10.1177/20406223241301892 |
| spellingShingle | Wen-Kai Chu Leay Kiaw Er Chin-Chen Chang Jin-Ying Lu Wan-Chen Wu Yao-Chou Tsai Yen-Hung Lin Vin-Cent Wu Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study Therapeutic Advances in Chronic Disease |
| title | Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study |
| title_full | Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study |
| title_fullStr | Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study |
| title_full_unstemmed | Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study |
| title_short | Visceral adiposity as a predictor of new-onset diabetes in patients with primary aldosteronism: a cohort study |
| title_sort | visceral adiposity as a predictor of new onset diabetes in patients with primary aldosteronism a cohort study |
| url | https://doi.org/10.1177/20406223241301892 |
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