Evaluating a series of new curcumin derivatives as potential anti-breast cancer agents: A collective analysis of in-vitro and in-silico characterization
In this work, a series of curcumin derivatives have been synthesized using Claisen Schmidt condensation reaction & Schotten-Baumann reaction, and they were screened through in-silico and in-vitro analysis to determine their capacity as a potential agent against breast cancer. Molecular docki...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
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| Series: | Chemical Physics Impact |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266702242400207X |
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| Summary: | In this work, a series of curcumin derivatives have been synthesized using Claisen Schmidt condensation reaction & Schotten-Baumann reaction, and they were screened through in-silico and in-vitro analysis to determine their capacity as a potential agent against breast cancer. Molecular docking reveals that the compounds are in good fit in the active site region of the target protein. Anti-cancer activity reveals that compounds are highly active against the MCF-7 cell lines, even at low concentration. Among the synthesized compounds, a set of five (Group B) exhibits a nontoxic effect against normal cell lines even at high concentration, whereas the other set of six compounds (Group A) display a toxic effect. The drug likeliness and pharmacokinetic properties reveal that the compounds can be lead drug materials against breast cancer. |
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| ISSN: | 2667-0224 |