Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

IntroductionVoriconazole is widely used to prevent and treat invasive aspergillosis. However, its use is restricted by adverse effects, including acute liver injury (ALI). Patients with hepatic insufficiency are often more susceptible to voriconazole-induced liver injury than those with normal hepat...

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Bibliographic Details
Main Authors: Jing Ren, Xinfeng Cai, Wei Ge, Jinlin Guo, Shan Wang, Qinhui Wang, Linna Liu, Le Yang, Qi Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
hepatotoxicity
acute liver injury
therapeutic drug monitoring
trough concentration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1625003/full
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