Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures
Titanium-copper alloys are attracting interest for biological applications, but are still limited by the instinctive bioinertness of the material processed by conventional methods, which limits their application as potential bone implants. In this work, the hierarchical structures of porous Ti–Cu im...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S223878542402283X |
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| author | Na He Yumeng Du Jianying Wang Linlin Ji Mengzhen Zhu Yimou Luo Hailin Yang Jinglei Miao |
| author_facet | Na He Yumeng Du Jianying Wang Linlin Ji Mengzhen Zhu Yimou Luo Hailin Yang Jinglei Miao |
| author_sort | Na He |
| collection | DOAJ |
| description | Titanium-copper alloys are attracting interest for biological applications, but are still limited by the instinctive bioinertness of the material processed by conventional methods, which limits their application as potential bone implants. In this work, the hierarchical structures of porous Ti–Cu implants, which contain typical micro/nano sub-porous structure on the surface was successfully developed with the combination of the novel additive manufacture of laser powder bed fusion (L-PBF) and subsequent the micro arc oxidation (MAO) treatment. The high roughness, excellent hydrophilicity and the good match of mechanical properties were found on the micro/nano porous surface. And several compounds including TiO2-A, TiO2-R, CuO and Cu2O were also formed on the MAO-treated surface, which are all beneficial for the effectiveness improvement as biomaterials. The biological results conformed the obvious improvements in gain-of-function (GoF) of antibacterial properties and biological performances. All the samples for cell experiments exhibited a certain antibacterial function, in which no cytotoxicity and a significant promotion of the early adhesion for the MC3T3-E1 cells and BMSCs were detected in the MAO-treated samples. |
| format | Article |
| id | doaj-art-1ff3ed88f2ff4d75a6bb5243f721ad14 |
| institution | Kabale University |
| issn | 2238-7854 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj-art-1ff3ed88f2ff4d75a6bb5243f721ad142024-12-26T08:54:19ZengElsevierJournal of Materials Research and Technology2238-78542024-11-013336723683Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structuresNa He0Yumeng Du1Jianying Wang2Linlin Ji3Mengzhen Zhu4Yimou Luo5Hailin Yang6Jinglei Miao7State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, ChinaDepartment of Spine Surgery, Third Xiangya Hospital, Central South University, Changsha, 410000, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, ChinaDepartment of Endocrinology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, ChinaState Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, China; Corresponding author.Department of Spine Surgery, Third Xiangya Hospital, Central South University, Changsha, 410000, China; Corresponding author.Titanium-copper alloys are attracting interest for biological applications, but are still limited by the instinctive bioinertness of the material processed by conventional methods, which limits their application as potential bone implants. In this work, the hierarchical structures of porous Ti–Cu implants, which contain typical micro/nano sub-porous structure on the surface was successfully developed with the combination of the novel additive manufacture of laser powder bed fusion (L-PBF) and subsequent the micro arc oxidation (MAO) treatment. The high roughness, excellent hydrophilicity and the good match of mechanical properties were found on the micro/nano porous surface. And several compounds including TiO2-A, TiO2-R, CuO and Cu2O were also formed on the MAO-treated surface, which are all beneficial for the effectiveness improvement as biomaterials. The biological results conformed the obvious improvements in gain-of-function (GoF) of antibacterial properties and biological performances. All the samples for cell experiments exhibited a certain antibacterial function, in which no cytotoxicity and a significant promotion of the early adhesion for the MC3T3-E1 cells and BMSCs were detected in the MAO-treated samples.http://www.sciencedirect.com/science/article/pii/S223878542402283XTi-Cu alloysMicro arc oxidationHierarchical structuresAntibacterial propertiesCompatibilityOsteogenic properties |
| spellingShingle | Na He Yumeng Du Jianying Wang Linlin Ji Mengzhen Zhu Yimou Luo Hailin Yang Jinglei Miao Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures Journal of Materials Research and Technology Ti-Cu alloys Micro arc oxidation Hierarchical structures Antibacterial properties Compatibility Osteogenic properties |
| title | Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures |
| title_full | Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures |
| title_fullStr | Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures |
| title_full_unstemmed | Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures |
| title_short | Optimizing bio-functional properties of Ti–Cu bone implants through introducing hierarchical structures |
| title_sort | optimizing bio functional properties of ti cu bone implants through introducing hierarchical structures |
| topic | Ti-Cu alloys Micro arc oxidation Hierarchical structures Antibacterial properties Compatibility Osteogenic properties |
| url | http://www.sciencedirect.com/science/article/pii/S223878542402283X |
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