Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight
Background. Cholestasis is a common but serious clinical condition in preterm neonates. The current management for preterm neonatal cholestasis has limitations. The aim of this study was to determine effects of Bifidobacterium supplementation on the prevention and alleviation of cholestasis in prete...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/4625315 |
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| author | Gaohong Wu Xiaoqian Chen Ningxun Cui Yunxia He Jiaying Fan Dongya Yan Xueping Zhu Xiaoli Zhu |
| author_facet | Gaohong Wu Xiaoqian Chen Ningxun Cui Yunxia He Jiaying Fan Dongya Yan Xueping Zhu Xiaoli Zhu |
| author_sort | Gaohong Wu |
| collection | DOAJ |
| description | Background. Cholestasis is a common but serious clinical condition in preterm neonates. The current management for preterm neonatal cholestasis has limitations. The aim of this study was to determine effects of Bifidobacterium supplementation on the prevention and alleviation of cholestasis in preterm infants with very low birth weight. Methods. Preterm neonates with very low birth weight were enrolled in the Children’s Hospital of Soochow University between December 2012 and December 2017. The patients were randomly assigned into Bifidobacterium and control groups, and effects of Bifidobacterium supplementation on the outcomes were compared between the two groups. Results. There was no significant difference in the baseline characteristics in the two groups. Notably, the proportion of cases with neonatal cholestasis was significantly lower, with fewer neonatal cholestasis-associated complications in the Bifidobacterium group compared with the control group (6% versus 22%, P<0.01). Furthermore, the Bifidobacterium group exhibited less severe cholestasis and better improvement of the liver function than the control group as evidenced by the biochemical tests (P<0.05). Finally, comparison of the other outcomes revealed that significant shorter duration of hospitalization (14.45±2.13 versus 16.12±2.22 days, P<0.01), fewer days to reach the full enteral feeding (9.2±2.11 versus 12±5.67 days, P<0.01), shorter duration of meconium passage (5.0±3.6 versus 6.6±3.38 days, P<0.05), lower proportion of cases on fasting and duration of fasting (0.8% versus 5.6%, P<0.05 and 3.0±1.6 versus 5.6±2.38 days, P<0.01, respectively), and shorter duration of weight gain to normal (4.77±2.49 versus 6.87±2.71 days, P<0.01) in the Bifidobacterium group versus the control group. Conclusions. Bifidobacterium supplementation has significantly preventive and other beneficial effects on the management of cholestasis in preterm infants with very low birth weight. Its long-term safety and effectiveness will need further investigation. This trial is registered with the Chinese Clinical Trial Registry (Registration No. ChiCTR1900022296). |
| format | Article |
| id | doaj-art-1fee51c2ffc54d25b55f7c2cbfe00b43 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-1fee51c2ffc54d25b55f7c2cbfe00b432025-08-20T03:54:34ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/46253154625315Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth WeightGaohong Wu0Xiaoqian Chen1Ningxun Cui2Yunxia He3Jiaying Fan4Dongya Yan5Xueping Zhu6Xiaoli Zhu7Department of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, ChinaDepartment of Neonatology, Children’s Hospital of Soochow University, Suzhou, Jiangsu 215025, ChinaDepartment of Intervention, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaBackground. Cholestasis is a common but serious clinical condition in preterm neonates. The current management for preterm neonatal cholestasis has limitations. The aim of this study was to determine effects of Bifidobacterium supplementation on the prevention and alleviation of cholestasis in preterm infants with very low birth weight. Methods. Preterm neonates with very low birth weight were enrolled in the Children’s Hospital of Soochow University between December 2012 and December 2017. The patients were randomly assigned into Bifidobacterium and control groups, and effects of Bifidobacterium supplementation on the outcomes were compared between the two groups. Results. There was no significant difference in the baseline characteristics in the two groups. Notably, the proportion of cases with neonatal cholestasis was significantly lower, with fewer neonatal cholestasis-associated complications in the Bifidobacterium group compared with the control group (6% versus 22%, P<0.01). Furthermore, the Bifidobacterium group exhibited less severe cholestasis and better improvement of the liver function than the control group as evidenced by the biochemical tests (P<0.05). Finally, comparison of the other outcomes revealed that significant shorter duration of hospitalization (14.45±2.13 versus 16.12±2.22 days, P<0.01), fewer days to reach the full enteral feeding (9.2±2.11 versus 12±5.67 days, P<0.01), shorter duration of meconium passage (5.0±3.6 versus 6.6±3.38 days, P<0.05), lower proportion of cases on fasting and duration of fasting (0.8% versus 5.6%, P<0.05 and 3.0±1.6 versus 5.6±2.38 days, P<0.01, respectively), and shorter duration of weight gain to normal (4.77±2.49 versus 6.87±2.71 days, P<0.01) in the Bifidobacterium group versus the control group. Conclusions. Bifidobacterium supplementation has significantly preventive and other beneficial effects on the management of cholestasis in preterm infants with very low birth weight. Its long-term safety and effectiveness will need further investigation. This trial is registered with the Chinese Clinical Trial Registry (Registration No. ChiCTR1900022296).http://dx.doi.org/10.1155/2020/4625315 |
| spellingShingle | Gaohong Wu Xiaoqian Chen Ningxun Cui Yunxia He Jiaying Fan Dongya Yan Xueping Zhu Xiaoli Zhu Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight Gastroenterology Research and Practice |
| title | Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight |
| title_full | Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight |
| title_fullStr | Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight |
| title_full_unstemmed | Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight |
| title_short | Preventive Effect of Bifidobacterium Supplementation on Neonatal Cholestasis in Preterm Neonates with Very Low Birth Weight |
| title_sort | preventive effect of bifidobacterium supplementation on neonatal cholestasis in preterm neonates with very low birth weight |
| url | http://dx.doi.org/10.1155/2020/4625315 |
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