Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study
BackgroundHigher intake of antioxidants is associated with reduced risk of various chronic diseases. However, the relationship between composite dietary antioxidants and frailty has not been characterized, especially in neurodegenerative conditions like Parkinson’s disease (PD) where frailty is high...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1502748/full |
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| author | Zhaohao Zeng Zhaohao Zeng Wen Jin Wen Jin Wen Jin Kunyu Huang Lijiao Xiong Lijiao Xiong Yu Luo Yu Luo Guoyang Li Guoyang Li Wenli Zhang Wenli Zhang Guo Hong Guo Hong Fengju Mao Fengju Mao Kaifen Xiong Kaifen Xiong Xiaoguang Luo Xiaoguang Luo |
| author_facet | Zhaohao Zeng Zhaohao Zeng Wen Jin Wen Jin Wen Jin Kunyu Huang Lijiao Xiong Lijiao Xiong Yu Luo Yu Luo Guoyang Li Guoyang Li Wenli Zhang Wenli Zhang Guo Hong Guo Hong Fengju Mao Fengju Mao Kaifen Xiong Kaifen Xiong Xiaoguang Luo Xiaoguang Luo |
| author_sort | Zhaohao Zeng |
| collection | DOAJ |
| description | BackgroundHigher intake of antioxidants is associated with reduced risk of various chronic diseases. However, the relationship between composite dietary antioxidants and frailty has not been characterized, especially in neurodegenerative conditions like Parkinson’s disease (PD) where frailty is highly prevalent. This study aimed to investigate the association between composite dietary antioxidant index (CDAI), a composite score reflecting antioxidant vitamin and mineral intakes, and frailty risk in the general United States (US) population and PD patients.MethodsData from 21,354 participants ≥40 years in the National Health and Nutrition Examination Survey (NHANES) 2003–2018 represented the general population sample, while 268 PD patients were analyzed separately. Frailty was defined using a validated index. Weighted logistic regression and restricted cubic splines (RCS) examined overall and nonlinear CDAI-frailty associations, adjusting for sociodemographics, lifestyle factors, and comorbidities.ResultsIn the general population, each unit increase in CDAI was associated with a 3.7% lower likelihood of frailty after full adjustments. Vitamin A, C, E, selenium and carotenoids exhibited J-shaped relationships where frailty risk decreased below intake thresholds of 1093.04 μg, 161.53 mg, 13.66 mg, 109.99 μg, and 5057.50 μg, respectively. In contrast, the CDAI- frailty inverse association was weaker among PD patients and only vitamin C (threshold 52.45 mg) and zinc (9.35 mg) showed nonlinear links.ConclusionHigher dietary antioxidant intake was associated with lower frailty prevalence in the general US population, with vitamins A, C, E, selenium, and carotenoids exhibiting nonlinear J-shaped relationships. In contrast, these associations were weaker and less consistent among PD patients, with only vitamins C and zinc showing nonlinear correlations. These findings highlight population-specific differences in the role of dietary antioxidants in frailty and suggest the need for personalized nutritional strategies in PD frailty management. |
| format | Article |
| id | doaj-art-1fc6ac162a0741ceb48af0d3878a566f |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-11-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-1fc6ac162a0741ceb48af0d3878a566f2024-11-28T14:39:35ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.15027481502748Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional studyZhaohao Zeng0Zhaohao Zeng1Wen Jin2Wen Jin3Wen Jin4Kunyu Huang5Lijiao Xiong6Lijiao Xiong7Yu Luo8Yu Luo9Guoyang Li10Guoyang Li11Wenli Zhang12Wenli Zhang13Guo Hong14Guo Hong15Fengju Mao16Fengju Mao17Kaifen Xiong18Kaifen Xiong19Xiaoguang Luo20Xiaoguang Luo21Department of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaPost-doctoral Scientific Research Station of Basic Medicine, Jinan University, Guangzhou, ChinaDepartment of Pharmacy, Shenshan Medical Center, Memorial Hospital of SUN YAT-SEN University, Shanwei, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaDepartment of Neurology, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaThe Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatrics, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, ChinaBackgroundHigher intake of antioxidants is associated with reduced risk of various chronic diseases. However, the relationship between composite dietary antioxidants and frailty has not been characterized, especially in neurodegenerative conditions like Parkinson’s disease (PD) where frailty is highly prevalent. This study aimed to investigate the association between composite dietary antioxidant index (CDAI), a composite score reflecting antioxidant vitamin and mineral intakes, and frailty risk in the general United States (US) population and PD patients.MethodsData from 21,354 participants ≥40 years in the National Health and Nutrition Examination Survey (NHANES) 2003–2018 represented the general population sample, while 268 PD patients were analyzed separately. Frailty was defined using a validated index. Weighted logistic regression and restricted cubic splines (RCS) examined overall and nonlinear CDAI-frailty associations, adjusting for sociodemographics, lifestyle factors, and comorbidities.ResultsIn the general population, each unit increase in CDAI was associated with a 3.7% lower likelihood of frailty after full adjustments. Vitamin A, C, E, selenium and carotenoids exhibited J-shaped relationships where frailty risk decreased below intake thresholds of 1093.04 μg, 161.53 mg, 13.66 mg, 109.99 μg, and 5057.50 μg, respectively. In contrast, the CDAI- frailty inverse association was weaker among PD patients and only vitamin C (threshold 52.45 mg) and zinc (9.35 mg) showed nonlinear links.ConclusionHigher dietary antioxidant intake was associated with lower frailty prevalence in the general US population, with vitamins A, C, E, selenium, and carotenoids exhibiting nonlinear J-shaped relationships. In contrast, these associations were weaker and less consistent among PD patients, with only vitamins C and zinc showing nonlinear correlations. These findings highlight population-specific differences in the role of dietary antioxidants in frailty and suggest the need for personalized nutritional strategies in PD frailty management.https://www.frontiersin.org/articles/10.3389/fnut.2024.1502748/fullcomposite dietary antioxidant indexfrailtyParkinson’s diseaserestricted cubic splinesnational health and nutrition examination survey |
| spellingShingle | Zhaohao Zeng Zhaohao Zeng Wen Jin Wen Jin Wen Jin Kunyu Huang Lijiao Xiong Lijiao Xiong Yu Luo Yu Luo Guoyang Li Guoyang Li Wenli Zhang Wenli Zhang Guo Hong Guo Hong Fengju Mao Fengju Mao Kaifen Xiong Kaifen Xiong Xiaoguang Luo Xiaoguang Luo Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study Frontiers in Nutrition composite dietary antioxidant index frailty Parkinson’s disease restricted cubic splines national health and nutrition examination survey |
| title | Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study |
| title_full | Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study |
| title_fullStr | Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study |
| title_full_unstemmed | Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study |
| title_short | Examining the relationship between CDAI and frailty and its manifestation in Parkinson’s disease: a cross-sectional study |
| title_sort | examining the relationship between cdai and frailty and its manifestation in parkinson s disease a cross sectional study |
| topic | composite dietary antioxidant index frailty Parkinson’s disease restricted cubic splines national health and nutrition examination survey |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1502748/full |
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