Development of a novel single channel arteriole microphysiological system for characterizing leukocyte-endothelial interactions

Development of a novel single channel arteriole microphysiological system for characterizing leukocyte-endothelial interactions

Abstract Background: Here we present a novel approach to evaluate peripheral blood mononuclear cell vascular adhesion using a microfluidic model designed to approximate the complexity of a human arteriole. While EC monolayer assays are commonly used to investigate leukocyte-EC interactions, we hyp...

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Bibliographic Details
Main Authors: Sebastian Piombo, Christopher J. Hatch, Chauncey G. Evangelista, Shlomit Radom-Aizik, Dan M. Cooper, Christopher C.W. Hughes
Format: Article
Language:English
Published: Cambridge University Press 2025-01-01
Series:Journal of Clinical and Translational Science
Subjects:
Atherosclerosis
microphysiological systems
device design
inflammatory disease
pediatric origins
Online Access:https://www.cambridge.org/core/product/identifier/S2059866125000494/type/journal_article
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