The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis
Both irreversible electroporation (IRE) and radiofrequency ablation (RFA) are viable ablation methods for localized treatment of liver tumors. We conducted a meta-analysis to access the efficacy and safety of IRE and RFA in liver cancer treatment. Clinical studies on IRE and RFA for the treatment of...
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De Gruyter
2024-12-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-0991 |
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| author | Xing Rong Liu Yutong Liu Yang Jiang Haihong Liu Chao Du Jiru |
| author_facet | Xing Rong Liu Yutong Liu Yang Jiang Haihong Liu Chao Du Jiru |
| author_sort | Xing Rong |
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| description | Both irreversible electroporation (IRE) and radiofrequency ablation (RFA) are viable ablation methods for localized treatment of liver tumors. We conducted a meta-analysis to access the efficacy and safety of IRE and RFA in liver cancer treatment. Clinical studies on IRE and RFA for the treatment of liver cancer were collected from PubMed and CNKI until June 2023. We screened the literature for ablation success rates at 1 month post-operation, extracting keywords such as “ablation success rate,” “technical success rate,” “recurrence rate,” and “complication” for meta-analysis. A total of 37 articles were included: 24 related to RFA involving 1,685 cases and 13 related to IRE involving 524 cases. The results demonstrate that ablation success rates at post-operative 1 month for IRE and RFA were 86% (95% CI: 82–89%) and 87% (95% CI: 81–92%), respectively. Technical success rates were 96% (95% CI: 88–100%) and 99% (95% CI: 96–100%). In addition, the recurrence rate was 16% (95% CI: 12–22%) in RFA group and 16% (95% CI: 9–23%) in IRE group. In terms of safety, the RFA had a complication rate of 28% (95% CI: 10–50%) and the IRE had a rate of 26% (95% CI: 13–43%). In conclusion, IRE and RFA exhibit similar ablation success rates at 1 month post-operation and comparable complication rates, making them both safe and effective treatment options. |
| format | Article |
| id | doaj-art-1fa28b0ac63e48098eb3df80b2a7b3a7 |
| institution | Kabale University |
| issn | 2391-5412 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
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| series | Open Life Sciences |
| spelling | doaj-art-1fa28b0ac63e48098eb3df80b2a7b3a72025-01-02T05:56:21ZengDe GruyterOpen Life Sciences2391-54122024-12-011911005786910.1515/biol-2022-0991The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysisXing Rong0Liu Yutong1Liu Yang2Jiang Haihong3Liu Chao4Du Jiru5School of Medical Devices, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, ChinaSchool of Medical Devices, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, ChinaSchool of Medical Devices, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, ChinaSchool of Medical Devices, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, ChinaLiver Disease Center, The Affiliated Hospital of Qingdao University, Shanghai, 266003, ChinaSchool infirmary, Fudan University, Shanghai, 200433, ChinaBoth irreversible electroporation (IRE) and radiofrequency ablation (RFA) are viable ablation methods for localized treatment of liver tumors. We conducted a meta-analysis to access the efficacy and safety of IRE and RFA in liver cancer treatment. Clinical studies on IRE and RFA for the treatment of liver cancer were collected from PubMed and CNKI until June 2023. We screened the literature for ablation success rates at 1 month post-operation, extracting keywords such as “ablation success rate,” “technical success rate,” “recurrence rate,” and “complication” for meta-analysis. A total of 37 articles were included: 24 related to RFA involving 1,685 cases and 13 related to IRE involving 524 cases. The results demonstrate that ablation success rates at post-operative 1 month for IRE and RFA were 86% (95% CI: 82–89%) and 87% (95% CI: 81–92%), respectively. Technical success rates were 96% (95% CI: 88–100%) and 99% (95% CI: 96–100%). In addition, the recurrence rate was 16% (95% CI: 12–22%) in RFA group and 16% (95% CI: 9–23%) in IRE group. In terms of safety, the RFA had a complication rate of 28% (95% CI: 10–50%) and the IRE had a rate of 26% (95% CI: 13–43%). In conclusion, IRE and RFA exhibit similar ablation success rates at 1 month post-operation and comparable complication rates, making them both safe and effective treatment options.https://doi.org/10.1515/biol-2022-0991irreversible electroporationradiofrequencyliver cancermeta-analysis |
| spellingShingle | Xing Rong Liu Yutong Liu Yang Jiang Haihong Liu Chao Du Jiru The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis Open Life Sciences irreversible electroporation radiofrequency liver cancer meta-analysis |
| title | The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis |
| title_full | The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis |
| title_fullStr | The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis |
| title_full_unstemmed | The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis |
| title_short | The debate between electricity and heat, efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer: A meta-analysis |
| title_sort | debate between electricity and heat efficacy and safety of irreversible electroporation and radiofrequency ablation in the treatment of liver cancer a meta analysis |
| topic | irreversible electroporation radiofrequency liver cancer meta-analysis |
| url | https://doi.org/10.1515/biol-2022-0991 |
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