Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review
Objective To conduct a scoping review of the literature on apathy in Parkinson’s disease (PD), to better understand how apathy in Parkinson’s disease is diagnosed, treated and managed.Methods MEDLINE, Embase, PsycINFO, CINAHL, Cochrane Central Register of Control Trials and Cochrane Database of Syst...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e037632.full |
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| author | Zahinoor Ismail Jayna Holroyd-Leduc Tamara Pringsheim Zahra Goodarzi Bria Mele Shinia Van |
| author_facet | Zahinoor Ismail Jayna Holroyd-Leduc Tamara Pringsheim Zahra Goodarzi Bria Mele Shinia Van |
| author_sort | Zahinoor Ismail |
| collection | DOAJ |
| description | Objective To conduct a scoping review of the literature on apathy in Parkinson’s disease (PD), to better understand how apathy in Parkinson’s disease is diagnosed, treated and managed.Methods MEDLINE, Embase, PsycINFO, CINAHL, Cochrane Central Register of Control Trials and Cochrane Database of Systematic Reviews were searched to 17 May 2017. An updated review was run from 17 May 2017 to 28 January 2019. The grey literature was searched using the CADTH Grey Matters tool. Original peer-reviewed research was included if it included individuals with PD and apathy. Non-original data was only included if it was in the form of meta-analysis. All information regarding diagnosis, treatment and management of PD was extracted. Citation screening and extraction were performed in duplicate.Results From 11 375 citations, 362 articles were included in the final review. The majority of included studies focussed on prevalence, with few studies examining treatment. Twenty screening tools for apathy were identified. Fifty per cent of treatment studies were randomised control trials (RCTs). RCTs applied treatment methods including: exercise, mindfulness, rotigotine (Neupro) transdermal patch and rivastigmine (Exelon).Conclusions This review identified a large body of literature describing current knowledge on diagnosing, treating and managing apathy in PD. Future research should aim to detect an ideal screening tool for apathy in PD, to identify the best treatment options for apathy and the variety of comorbidities it may present with and finally aim to better understand postoperative apathy in those with deep brain stimulation. |
| format | Article |
| id | doaj-art-1f988eebf81940f084bf2dd213fa8e9b |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-1f988eebf81940f084bf2dd213fa8e9b2025-01-08T05:30:09ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-037632Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping reviewZahinoor Ismail0Jayna Holroyd-Leduc1Tamara Pringsheim2Zahra Goodarzi3Bria Mele4Shinia Van5Department of Community Health Sciences & O’Brien Institute of Public Health, University of Calgary, Calgary, Alberta, CanadaAlberta Health Services, Calgary, Alberta, CanadaDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta, CanadaDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, CanadaDepartment of Community Health Sciences, University of Calgary, Calgary, Alberta, CanadaCumming School of Medicine, University of Calgary, Calgary, Alberta, CanadaObjective To conduct a scoping review of the literature on apathy in Parkinson’s disease (PD), to better understand how apathy in Parkinson’s disease is diagnosed, treated and managed.Methods MEDLINE, Embase, PsycINFO, CINAHL, Cochrane Central Register of Control Trials and Cochrane Database of Systematic Reviews were searched to 17 May 2017. An updated review was run from 17 May 2017 to 28 January 2019. The grey literature was searched using the CADTH Grey Matters tool. Original peer-reviewed research was included if it included individuals with PD and apathy. Non-original data was only included if it was in the form of meta-analysis. All information regarding diagnosis, treatment and management of PD was extracted. Citation screening and extraction were performed in duplicate.Results From 11 375 citations, 362 articles were included in the final review. The majority of included studies focussed on prevalence, with few studies examining treatment. Twenty screening tools for apathy were identified. Fifty per cent of treatment studies were randomised control trials (RCTs). RCTs applied treatment methods including: exercise, mindfulness, rotigotine (Neupro) transdermal patch and rivastigmine (Exelon).Conclusions This review identified a large body of literature describing current knowledge on diagnosing, treating and managing apathy in PD. Future research should aim to detect an ideal screening tool for apathy in PD, to identify the best treatment options for apathy and the variety of comorbidities it may present with and finally aim to better understand postoperative apathy in those with deep brain stimulation.https://bmjopen.bmj.com/content/10/9/e037632.full |
| spellingShingle | Zahinoor Ismail Jayna Holroyd-Leduc Tamara Pringsheim Zahra Goodarzi Bria Mele Shinia Van Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review BMJ Open |
| title | Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review |
| title_full | Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review |
| title_fullStr | Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review |
| title_full_unstemmed | Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review |
| title_short | Diagnosis, treatment and management of apathy in Parkinson’s disease: a scoping review |
| title_sort | diagnosis treatment and management of apathy in parkinson s disease a scoping review |
| url | https://bmjopen.bmj.com/content/10/9/e037632.full |
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