Echocardiographic findings and subsequent risk of native valve endocarditis

Echocardiographic findings and subsequent risk of native valve endocarditis

Aim: The association of echocardiographic findings and subsequent risk of left-sided native valve endocarditis (LS-NVE) is undefined. The aim of this study was to determine if transthoracic echocardiography (TTE) measurements are associated with the subsequent development of LS-NVE in patients witho...

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Main Authors: Juan A. Quintero-Martinez, Joya-Rita Hindy, Hector R. Villarraga, Brian D. Lahr, Mark J. Dayer, Martin H. Thornhill, John C. O’Horo, Hector I. Michelena, Nandan S. Anavekar, Parham Sendi, Daniel C. DeSimone, Larry M. Baddour
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2024-09-01
Series:Exploration of Cardiology
Subjects:
endocarditis
echocardiography
native valve
left-sided
measurements
risk
Online Access:https://www.explorationpub.com/uploads/Article/A101234/101234.pdf
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Summary:Aim: The association of echocardiographic findings and subsequent risk of left-sided native valve endocarditis (LS-NVE) is undefined. The aim of this study was to determine if transthoracic echocardiography (TTE) measurements are associated with the subsequent development of LS-NVE in patients without cardiac predisposing conditions. Methods: Institutional databases were evaluated for adults diagnosed with LS-NVE from 2008 to 2020. Patients with prosthetic valves, cardiovascular implantable electronic devices, intracardiac devices, injection drug use, and predisposing cardiac conditions were excluded. Only patients who had a TTE performed 6 months to 3 years before the development of LS-NVE were included as cases. Controls were patients within the same Mayo location with a TTE report and were matched in a 1:3 ratio according to age, gender, Charlson comorbidity index, and echocardiography date. Results: There were 148 cases and 431 matched controls. As compared to controls, infective endocarditis (IE) cases had a higher prevalence of diabetes mellitus (46.6% vs. 30.4%) and chronic kidney disease (46.6% vs. 28.1%) (P < 0.001). Left ventricular outflow tract velocity (P = 0.017), left ventricular ejection fraction (P = 0.018), and E:e’ ratio (P = 0.050) were associated with LS-NVE. Conclusions: Echocardiographic measurements were associated with subsequent LS-NVE development in this pilot study. A larger cohort of LS-NVE patients, however, is needed to validate these findings.
ISSN:2994-5526

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