Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis
Ulcerative colitis (UC) is a chronic colonic mucosal inflammation characterized by reduced gut microbial diversity. Patients with UC at pregnancy are prone to suffer from severe disease progression due to the changes of hormone and immune regulation. Fecal microbiota transplant (FMT) is a promising...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1417003/full |
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| author | Hanyu Wang Hanyu Wang Feihong Deng Feihong Deng Min Luo Min Luo Xuehong Wang Xuehong Wang |
| author_facet | Hanyu Wang Hanyu Wang Feihong Deng Feihong Deng Min Luo Min Luo Xuehong Wang Xuehong Wang |
| author_sort | Hanyu Wang |
| collection | DOAJ |
| description | Ulcerative colitis (UC) is a chronic colonic mucosal inflammation characterized by reduced gut microbial diversity. Patients with UC at pregnancy are prone to suffer from severe disease progression due to the changes of hormone and immune regulation. Fecal microbiota transplant (FMT) is a promising therapy for UC and recurrent Clostridium difficile infection (CDI). However, acute severe ulcerative colitis (ASUC) treatment especially in patients at pregnancy is clinically challenging. Herein, we report a 34-year-old pregnant woman who manifested with numerous bloody stools and markedly elevated serological inflammatory indicators and was diagnosed with ASUC and concurrent CDI. The use of intravenous injection steroids and anti-TNF-α therapy failed to improve her condition. Frozen encapsulated FMT therapy was finally performed to this patient with clearly improved symptoms and indications of safe delivery without UC flares or complications, and markedly increased diversity of the gut microbiota was also shown in this patient after FMT. This report firstly describes FMT as a safe salvage therapy for a pregnant patient with CDI and ASUC refractory to intravenous steroids and anti-TNF therapy. |
| format | Article |
| id | doaj-art-1f3aa8a91a2948138e231af76257de62 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1f3aa8a91a2948138e231af76257de622024-11-21T14:17:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14170031417003Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitisHanyu Wang0Hanyu Wang1Feihong Deng2Feihong Deng3Min Luo4Min Luo5Xuehong Wang6Xuehong Wang7Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaResearch Center of Digestive Disease, Central South University, Changsha, Hunan, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaResearch Center of Digestive Disease, Central South University, Changsha, Hunan, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaResearch Center of Digestive Disease, Central South University, Changsha, Hunan, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaResearch Center of Digestive Disease, Central South University, Changsha, Hunan, ChinaUlcerative colitis (UC) is a chronic colonic mucosal inflammation characterized by reduced gut microbial diversity. Patients with UC at pregnancy are prone to suffer from severe disease progression due to the changes of hormone and immune regulation. Fecal microbiota transplant (FMT) is a promising therapy for UC and recurrent Clostridium difficile infection (CDI). However, acute severe ulcerative colitis (ASUC) treatment especially in patients at pregnancy is clinically challenging. Herein, we report a 34-year-old pregnant woman who manifested with numerous bloody stools and markedly elevated serological inflammatory indicators and was diagnosed with ASUC and concurrent CDI. The use of intravenous injection steroids and anti-TNF-α therapy failed to improve her condition. Frozen encapsulated FMT therapy was finally performed to this patient with clearly improved symptoms and indications of safe delivery without UC flares or complications, and markedly increased diversity of the gut microbiota was also shown in this patient after FMT. This report firstly describes FMT as a safe salvage therapy for a pregnant patient with CDI and ASUC refractory to intravenous steroids and anti-TNF therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1417003/fullacute severe ulcerative colitisfecal microbiota transplantClostridium difficile infectionpregnancygut microbiota |
| spellingShingle | Hanyu Wang Hanyu Wang Feihong Deng Feihong Deng Min Luo Min Luo Xuehong Wang Xuehong Wang Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis Frontiers in Immunology acute severe ulcerative colitis fecal microbiota transplant Clostridium difficile infection pregnancy gut microbiota |
| title | Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis |
| title_full | Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis |
| title_fullStr | Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis |
| title_full_unstemmed | Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis |
| title_short | Case report: Fecal microbiota transplant for Clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis |
| title_sort | case report fecal microbiota transplant for clostridium difficile infection in a pregnant patient with acute severe ulcerative colitis |
| topic | acute severe ulcerative colitis fecal microbiota transplant Clostridium difficile infection pregnancy gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1417003/full |
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