Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish population
The aim of this study was to investigate a possible association between the variations and effects of gene changes in the OX40/OX40L pathway and the risk of developing bladder cancer in a Turkish population. The study included 104 patients with bladder cancer and 97 healthy individuals. The distribu...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-03-01
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| Series: | Biotechnology & Biotechnological Equipment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13102818.2023.2245923 |
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| author | Osman Bilen Levent Verim Cagatay Tosun Omer Yuksel Ulgen Sever Dilara Sonmez Mehmet Tolgahan Hakan Ilhan Yaylim |
| author_facet | Osman Bilen Levent Verim Cagatay Tosun Omer Yuksel Ulgen Sever Dilara Sonmez Mehmet Tolgahan Hakan Ilhan Yaylim |
| author_sort | Osman Bilen |
| collection | DOAJ |
| description | The aim of this study was to investigate a possible association between the variations and effects of gene changes in the OX40/OX40L pathway and the risk of developing bladder cancer in a Turkish population. The study included 104 patients with bladder cancer and 97 healthy individuals. The distribution of OX40 (rs17568) and OX40L (rs1234313) polymorphisms was evaluated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The genotype distributions of OX40 rs17568 regions showed non-significant differences between the patient and control groups (p = 0.256). No difference was also found in T2 invasive tumours, high, and low-grade tumours. The genotype distributions of the OX40L rs1234313 region were significantly different between the patient and control groups (p = 0.023). The frequency of the GG genotype and homozygous GG/AA genotypes was higher among the patients than in the control group, and the difference was significant (for GG genotype: OR 0.462; 95% CI 0.255–0.835; p = 0.010; for GG/AA genotype: OR 0.456 (0.257–0.808; p: 0.007). The OX40L A allele (AA/AG) had higher frequency in T2 invasive bladder cancer patients than in those with T1 and Ta (p = 0.028). There was no statistically significant difference in the OX40L genotype distributions among the graded tumour groups (p = 0.689). The results indicate that the rs1234313 A/G gene polymorphism may contribute to the development of bladder cancer in this Turkish population. Further observations in a larger cohort need to confirm this suggestion. |
| format | Article |
| id | doaj-art-1f3a1f3c53334fccbd1f631dc93a9da6 |
| institution | Kabale University |
| issn | 1310-2818 1314-3530 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj-art-1f3a1f3c53334fccbd1f631dc93a9da62024-11-25T09:24:35ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302023-03-0137110.1080/13102818.2023.2245923Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish populationOsman Bilen0Levent Verim1Cagatay Tosun2Omer Yuksel3Ulgen Sever4Dilara Sonmez5Mehmet Tolgahan Hakan6Ilhan Yaylim7Urology Department, Haydarpasa Numune Training Hospital, Istanbul, TurkeyUrology Department, Haydarpasa Numune Training Hospital, Istanbul, TurkeyUrology Department, Haydarpasa Numune Training Hospital, Istanbul, TurkeyUrology Department, Haydarpasa Numune Training Hospital, Istanbul, TurkeyDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, TurkeyDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, TurkeyDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, TurkeyDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, TurkeyThe aim of this study was to investigate a possible association between the variations and effects of gene changes in the OX40/OX40L pathway and the risk of developing bladder cancer in a Turkish population. The study included 104 patients with bladder cancer and 97 healthy individuals. The distribution of OX40 (rs17568) and OX40L (rs1234313) polymorphisms was evaluated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The genotype distributions of OX40 rs17568 regions showed non-significant differences between the patient and control groups (p = 0.256). No difference was also found in T2 invasive tumours, high, and low-grade tumours. The genotype distributions of the OX40L rs1234313 region were significantly different between the patient and control groups (p = 0.023). The frequency of the GG genotype and homozygous GG/AA genotypes was higher among the patients than in the control group, and the difference was significant (for GG genotype: OR 0.462; 95% CI 0.255–0.835; p = 0.010; for GG/AA genotype: OR 0.456 (0.257–0.808; p: 0.007). The OX40L A allele (AA/AG) had higher frequency in T2 invasive bladder cancer patients than in those with T1 and Ta (p = 0.028). There was no statistically significant difference in the OX40L genotype distributions among the graded tumour groups (p = 0.689). The results indicate that the rs1234313 A/G gene polymorphism may contribute to the development of bladder cancer in this Turkish population. Further observations in a larger cohort need to confirm this suggestion.https://www.tandfonline.com/doi/10.1080/13102818.2023.2245923Bladder cancerOX40/OX40 ligandapoptosisgene polymorphism |
| spellingShingle | Osman Bilen Levent Verim Cagatay Tosun Omer Yuksel Ulgen Sever Dilara Sonmez Mehmet Tolgahan Hakan Ilhan Yaylim Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish population Biotechnology & Biotechnological Equipment Bladder cancer OX40/OX40 ligand apoptosis gene polymorphism |
| title | Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish population |
| title_full | Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish population |
| title_fullStr | Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish population |
| title_full_unstemmed | Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish population |
| title_short | Relationship between bladder cancer and polymorphisms of OX40 (rs17568) and OX40L (rs1234313) genes in a Turkish population |
| title_sort | relationship between bladder cancer and polymorphisms of ox40 rs17568 and ox40l rs1234313 genes in a turkish population |
| topic | Bladder cancer OX40/OX40 ligand apoptosis gene polymorphism |
| url | https://www.tandfonline.com/doi/10.1080/13102818.2023.2245923 |
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