Attenuation of cisplatin-induced acute kidney injury by sanguinarine: modulation of oxidative stress, inflammation, and cellular damage

Attenuation of cisplatin-induced acute kidney injury by sanguinarine: modulation of oxidative stress, inflammation, and cellular damage

IntroductionCisplatin (CP)-induced acute kidney injury (AKI) is a significant side effect of CP chemotherapy, driven by oxidative stress and inflammation. Sanguinarine (SANG), an alkaloid from the rhizomes of Sanguinaria canadensis and poppy-fumaria species, exhibits antioxidant and anti-inflammator...

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Main Authors: Nur Elena Zaaba, Suhail Al-Salam, Sumaya Beegam, Ozaz Elzaki, Fatima Aldhaheri, Anas Nemmar, Badreldin H. Ali, Abderrahim Nemmar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
sanguinarine
kidney injury
inflammation
oxidative stress
apoptosis
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1567888/full
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