Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases
The Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects. Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of th...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/9392132 |
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| author | Juan Shi Shuhong Chi Jing Xue Jiali Yang Feng Li Xiaoming Liu |
| author_facet | Juan Shi Shuhong Chi Jing Xue Jiali Yang Feng Li Xiaoming Liu |
| author_sort | Juan Shi |
| collection | DOAJ |
| description | The Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects. Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases. Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway. This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases. |
| format | Article |
| id | doaj-art-1ee8dd2673044451b6ef86a21afd9e02 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-1ee8dd2673044451b6ef86a21afd9e022025-02-03T05:53:04ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/93921329392132Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune DiseasesJuan Shi0Shuhong Chi1Jing Xue2Jiali Yang3Feng Li4Xiaoming Liu5Center of Laboratory Medicine, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaKey Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources of Western China, Ningxia University, Yinchuan, Ningxia 750021, ChinaCenter of Laboratory Medicine, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaCenter of Laboratory Medicine, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaKey Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources of Western China, Ningxia University, Yinchuan, Ningxia 750021, ChinaThe Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects. Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases. Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway. This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.http://dx.doi.org/10.1155/2016/9392132 |
| spellingShingle | Juan Shi Shuhong Chi Jing Xue Jiali Yang Feng Li Xiaoming Liu Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases Journal of Immunology Research |
| title | Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases |
| title_full | Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases |
| title_fullStr | Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases |
| title_full_unstemmed | Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases |
| title_short | Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases |
| title_sort | emerging role and therapeutic implication of wnt signaling pathways in autoimmune diseases |
| url | http://dx.doi.org/10.1155/2016/9392132 |
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