Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort study
Abstract Background The longitudinal changes in maternal serum ferritin (SF) levels across gestation, which indirectly reflect iron supplementation, have not been extensively investigated in relation to gestational diabetes mellitus (GDM). Methods We conducted a retrospective cohort study at a terti...
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Wiley
2024-11-01
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| Series: | Journal of Diabetes |
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| Online Access: | https://doi.org/10.1111/1753-0407.70027 |
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| author | Huiqin Mo Jingna Wen Cuicui Qu Xiaohua Liu |
| author_facet | Huiqin Mo Jingna Wen Cuicui Qu Xiaohua Liu |
| author_sort | Huiqin Mo |
| collection | DOAJ |
| description | Abstract Background The longitudinal changes in maternal serum ferritin (SF) levels across gestation, which indirectly reflect iron supplementation, have not been extensively investigated in relation to gestational diabetes mellitus (GDM). Methods We conducted a retrospective cohort study at a tertiary maternal hospital in Shanghai. Women with SF concentration measurements at 8.0–13.6 weeks' gestation (GW), 29.0–31.6 GW, and an oral glucose tolerance test (OGTT) at 24–28 GW were included. We utilized logistic regression analysis to assess GDM association with maternal SF levels and longitudinal changes. Results The study included 17 560 women, with 2160 (12.3%) participants diagnosed with GDM. Adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for GDM across increasing quartiles of SF concentrations at 8.0–13.6 GW were 1.00 (reference), 1.139 (95% CI: 1.012–1.283), 1.093 (95% CI: 0.969–1.233), and 1.248 (95% CI: 1.111–1.403). Similarly, at 29.0–31.6 GW, increasing quartiles of SF concentrations were associated with higher adjusted ORs for GDM: 1.00 (reference), 1.165 (95% CI: 1.029–1.320), 1.335 (95% CI: 1.184–1.505), and 1.428 (95% CI: 1.268–1.607). Pregnant women with higher SF levels (upper 25th percentile) at 8.0–13.6 GW had a reduced GDM risk if their SF levels decreased to the lower 25th percentile at 29.0–31.6 GW. Conversely, the subgroup with higher SF levels (upper 25th percentile) at both time points had the highest incidence rate of GDM (15.3%, 1.235 [95% CI: 1.087–1.404]). Conclusions Maternal SF levels independently and positively associated with GDM risk during early and late gestational stages. Considering the increased GDM risk, routine iron supplementation for iron‐replete women is questionable. |
| format | Article |
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| institution | Kabale University |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Journal of Diabetes |
| spelling | doaj-art-1ee60cef45a24fea8f6f59665087d94f2024-11-26T07:02:35ZengWileyJournal of Diabetes1753-03931753-04072024-11-011611n/an/a10.1111/1753-0407.70027Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort studyHuiqin Mo0Jingna Wen1Cuicui Qu2Xiaohua Liu3Department of Obstetrics, Shanghai Key Laboratory of Maternal and Fetal Medicine, Obstetrics and Gynecology Hospital Tongji University School of Medicine Shanghai ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal and Fetal Medicine, Obstetrics and Gynecology Hospital Tongji University School of Medicine Shanghai ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal and Fetal Medicine, Obstetrics and Gynecology Hospital Tongji University School of Medicine Shanghai ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal and Fetal Medicine, Obstetrics and Gynecology Hospital Tongji University School of Medicine Shanghai ChinaAbstract Background The longitudinal changes in maternal serum ferritin (SF) levels across gestation, which indirectly reflect iron supplementation, have not been extensively investigated in relation to gestational diabetes mellitus (GDM). Methods We conducted a retrospective cohort study at a tertiary maternal hospital in Shanghai. Women with SF concentration measurements at 8.0–13.6 weeks' gestation (GW), 29.0–31.6 GW, and an oral glucose tolerance test (OGTT) at 24–28 GW were included. We utilized logistic regression analysis to assess GDM association with maternal SF levels and longitudinal changes. Results The study included 17 560 women, with 2160 (12.3%) participants diagnosed with GDM. Adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for GDM across increasing quartiles of SF concentrations at 8.0–13.6 GW were 1.00 (reference), 1.139 (95% CI: 1.012–1.283), 1.093 (95% CI: 0.969–1.233), and 1.248 (95% CI: 1.111–1.403). Similarly, at 29.0–31.6 GW, increasing quartiles of SF concentrations were associated with higher adjusted ORs for GDM: 1.00 (reference), 1.165 (95% CI: 1.029–1.320), 1.335 (95% CI: 1.184–1.505), and 1.428 (95% CI: 1.268–1.607). Pregnant women with higher SF levels (upper 25th percentile) at 8.0–13.6 GW had a reduced GDM risk if their SF levels decreased to the lower 25th percentile at 29.0–31.6 GW. Conversely, the subgroup with higher SF levels (upper 25th percentile) at both time points had the highest incidence rate of GDM (15.3%, 1.235 [95% CI: 1.087–1.404]). Conclusions Maternal SF levels independently and positively associated with GDM risk during early and late gestational stages. Considering the increased GDM risk, routine iron supplementation for iron‐replete women is questionable.https://doi.org/10.1111/1753-0407.70027gestational diabetes mellitusiron supplementationlongitudinal changespregnant womenserum ferritin |
| spellingShingle | Huiqin Mo Jingna Wen Cuicui Qu Xiaohua Liu Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort study Journal of Diabetes gestational diabetes mellitus iron supplementation longitudinal changes pregnant women serum ferritin |
| title | Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort study |
| title_full | Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort study |
| title_fullStr | Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort study |
| title_full_unstemmed | Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort study |
| title_short | Associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus: A longitudinal cohort study |
| title_sort | associations of maternal serum ferritin levels across gestation with gestational diabetes mellitus a longitudinal cohort study |
| topic | gestational diabetes mellitus iron supplementation longitudinal changes pregnant women serum ferritin |
| url | https://doi.org/10.1111/1753-0407.70027 |
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