Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract
Green synthesis of nanomaterials is eco-friendly, cost effective approach. This work reports anti-cancer and antimicrobial properties of ZnO nanoparticles synthesized via green route using Amaranthus dubius leaf extract. XRD analysis confirmed the formation of highly pure ZnO nanoparticles with incr...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Green Chemistry Letters and Reviews |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/17518253.2025.2453532 |
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| author | Faaiza Naaz K Alavya Tiwari Aabid Hussain Shaik Indumathi P Brianna Brianna Ayaz Anwar Mohammed Rehaan Chandan |
| author_facet | Faaiza Naaz K Alavya Tiwari Aabid Hussain Shaik Indumathi P Brianna Brianna Ayaz Anwar Mohammed Rehaan Chandan |
| author_sort | Faaiza Naaz K |
| collection | DOAJ |
| description | Green synthesis of nanomaterials is eco-friendly, cost effective approach. This work reports anti-cancer and antimicrobial properties of ZnO nanoparticles synthesized via green route using Amaranthus dubius leaf extract. XRD analysis confirmed the formation of highly pure ZnO nanoparticles with increased crystallinity, exhibiting a particle size of ∼14 nm. The FTIR spectra indicated the formation of ZnO nanoparticles with distinct bands in the 400 and 600 cm−1 range, while SEM images revealed spherical-shaped nanoparticles, along with some flower-like structures, indicating a higher surface-to-volume ratio. The synthesized nanoparticles exhibited higher antimicrobial effects at 50 μg/mL with a maximum inhibitory zone diameter of 22 mm observed for B. cereus and 10 mm for S. aureus, E. coli, and Salmonella spp. Anti-cancer effects were evaluated against CCD112 normal colon cell line and HCT116 colorectal cancer cell line. The results demonstrated that ZnO nanoparticles were non-toxic to the normal cell line. At a concentration of 7.82 μg/mL, there was a 15.4% decrease in cell viability relative to the control in HCT116 cell lines, indicating cytotoxicity. At 125 μg/mL, the cells exhibited extreme cytotoxicity against cancer cell lines, with a viability of only 87.66%, showing a 12.3% decrease compared to the control. |
| format | Article |
| id | doaj-art-1ee133bb788c4b70b6ffb3b581d87adf |
| institution | Kabale University |
| issn | 1751-8253 1751-7192 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Green Chemistry Letters and Reviews |
| spelling | doaj-art-1ee133bb788c4b70b6ffb3b581d87adf2025-01-17T17:40:01ZengTaylor & Francis GroupGreen Chemistry Letters and Reviews1751-82531751-71922025-12-0118110.1080/17518253.2025.2453532Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extractFaaiza Naaz K0Alavya Tiwari1Aabid Hussain Shaik2Indumathi P3Brianna Brianna4Ayaz Anwar5Mohammed Rehaan Chandan6Department of Biochemistry, Auxilium College (Autonomous), Vellore, IndiaColloids and Polymers Research Group, School of Chemical Engineering, Vellore Institute of Technology, Vellore, IndiaColloids and Polymers Research Group, School of Chemical Engineering, Vellore Institute of Technology, Vellore, IndiaDepartment of Biochemistry, Auxilium College (Autonomous), Vellore, IndiaDepartment of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, MalaysiaDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, MalaysiaColloids and Polymers Research Group, School of Chemical Engineering, Vellore Institute of Technology, Vellore, IndiaGreen synthesis of nanomaterials is eco-friendly, cost effective approach. This work reports anti-cancer and antimicrobial properties of ZnO nanoparticles synthesized via green route using Amaranthus dubius leaf extract. XRD analysis confirmed the formation of highly pure ZnO nanoparticles with increased crystallinity, exhibiting a particle size of ∼14 nm. The FTIR spectra indicated the formation of ZnO nanoparticles with distinct bands in the 400 and 600 cm−1 range, while SEM images revealed spherical-shaped nanoparticles, along with some flower-like structures, indicating a higher surface-to-volume ratio. The synthesized nanoparticles exhibited higher antimicrobial effects at 50 μg/mL with a maximum inhibitory zone diameter of 22 mm observed for B. cereus and 10 mm for S. aureus, E. coli, and Salmonella spp. Anti-cancer effects were evaluated against CCD112 normal colon cell line and HCT116 colorectal cancer cell line. The results demonstrated that ZnO nanoparticles were non-toxic to the normal cell line. At a concentration of 7.82 μg/mL, there was a 15.4% decrease in cell viability relative to the control in HCT116 cell lines, indicating cytotoxicity. At 125 μg/mL, the cells exhibited extreme cytotoxicity against cancer cell lines, with a viability of only 87.66%, showing a 12.3% decrease compared to the control.https://www.tandfonline.com/doi/10.1080/17518253.2025.2453532ZnO nanoparticlesAmaranthus dubiusSpleen Amaranthantimicrobial applicationscytotoxicity assay |
| spellingShingle | Faaiza Naaz K Alavya Tiwari Aabid Hussain Shaik Indumathi P Brianna Brianna Ayaz Anwar Mohammed Rehaan Chandan Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract Green Chemistry Letters and Reviews ZnO nanoparticles Amaranthus dubius Spleen Amaranth antimicrobial applications cytotoxicity assay |
| title | Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract |
| title_full | Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract |
| title_fullStr | Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract |
| title_full_unstemmed | Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract |
| title_short | Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract |
| title_sort | anti cancer and antimicrobial efficacy of zno nanoparticles synthesized via green route using amaranthus dubius spleen amaranth leaves extract |
| topic | ZnO nanoparticles Amaranthus dubius Spleen Amaranth antimicrobial applications cytotoxicity assay |
| url | https://www.tandfonline.com/doi/10.1080/17518253.2025.2453532 |
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