The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo Nation
Objective: American Indian and Alaska Native people in the United States experience high rates of stomach cancer. Helicobacter pylori infection is a significant risk factor for stomach cancer, and H. pylori strains that carry the cagA gene are linked to greater gastrointestinal disease severity. Yet...
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| Format: | Article |
| Language: | English |
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Verduci Editore
2024-07-01
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| Series: | Microbiota in Health and Disease |
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| Online Access: | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/07/e1007.pdf |
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| author | D. Pete N. Salama J. Lampe M Wu A. Phipps |
| author_facet | D. Pete N. Salama J. Lampe M Wu A. Phipps |
| author_sort | D. Pete |
| collection | DOAJ |
| description | Objective: American Indian and Alaska Native people in the United States experience high rates of stomach cancer. Helicobacter pylori infection is a significant risk factor for stomach cancer, and H. pylori strains that carry the cagA gene are linked to greater gastrointestinal disease severity. Yet, little is known about H. pylori and cagA infections in American Indian and Alaska Native people, particularly at the tribal level. We assessed the prevalence and risk factors of H. pylori infection and cagA gene carriage in tribal members from the Navajo Nation.
Patients and Methods: We conducted a cross-sectional study with adults from the Navajo Nation. Stool samples collected from participants were analyzed with droplet digital PCR for H. pylori 16S ribosomal and cagA virulence genes. Self-administered health and food questionnaires were mailed to participants to collect information on sociodemographic, health, lifestyle, and environmental risk factors for H. pylori infection. Logistic regression assessed the association between risk factors and H. pylori infection and cagA gene carriage.
Results: Among 99 adults, the median age was 45 (age range: 18 to 79 years), and 73.7% were female. About 56.6% (95% CI: 46.2-66.5) of participants were infected with H. pylori. Of H. pylori-infected participants, 78.6% (95% CI: 65.6-88.4) were cagA-gene positive. No significant associations of relevant risk factors with H. pylori and cagA-gene positive infections were noted.
Conclusions: In a community-based study population, a substantial proportion of adult tribal members had H. pylori and cagA-gene positive infections. Given these high proportions, culturally appropriate prevention strategies and interventions addressing H. pylori infections present an avenue for additional research and stomach cancer prevention in the Navajo Nation. |
| format | Article |
| id | doaj-art-1ebae7e885be41c68e9297561e0011b2 |
| institution | Kabale University |
| issn | 2704-8845 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Microbiota in Health and Disease |
| spelling | doaj-art-1ebae7e885be41c68e9297561e0011b22025-01-03T10:30:12ZengVerduci EditoreMicrobiota in Health and Disease2704-88452024-07-01610.26355/mhd_20247_10071007The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo NationD. Pete0N. Salama1J. Lampe2M Wu3A. Phipps4Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USAHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USADepartment of Epidemiology, University of Washington School of Public Health, Seattle, WA, USAPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USADepartment of Epidemiology, University of Washington School of Public Health, Seattle, WA, USAObjective: American Indian and Alaska Native people in the United States experience high rates of stomach cancer. Helicobacter pylori infection is a significant risk factor for stomach cancer, and H. pylori strains that carry the cagA gene are linked to greater gastrointestinal disease severity. Yet, little is known about H. pylori and cagA infections in American Indian and Alaska Native people, particularly at the tribal level. We assessed the prevalence and risk factors of H. pylori infection and cagA gene carriage in tribal members from the Navajo Nation. Patients and Methods: We conducted a cross-sectional study with adults from the Navajo Nation. Stool samples collected from participants were analyzed with droplet digital PCR for H. pylori 16S ribosomal and cagA virulence genes. Self-administered health and food questionnaires were mailed to participants to collect information on sociodemographic, health, lifestyle, and environmental risk factors for H. pylori infection. Logistic regression assessed the association between risk factors and H. pylori infection and cagA gene carriage. Results: Among 99 adults, the median age was 45 (age range: 18 to 79 years), and 73.7% were female. About 56.6% (95% CI: 46.2-66.5) of participants were infected with H. pylori. Of H. pylori-infected participants, 78.6% (95% CI: 65.6-88.4) were cagA-gene positive. No significant associations of relevant risk factors with H. pylori and cagA-gene positive infections were noted. Conclusions: In a community-based study population, a substantial proportion of adult tribal members had H. pylori and cagA-gene positive infections. Given these high proportions, culturally appropriate prevention strategies and interventions addressing H. pylori infections present an avenue for additional research and stomach cancer prevention in the Navajo Nation.https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/07/e1007.pdfindigenousstomach cancercancer disparitiesrisk factorshelicobacter pyloricaga. |
| spellingShingle | D. Pete N. Salama J. Lampe M Wu A. Phipps The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo Nation Microbiota in Health and Disease indigenous stomach cancer cancer disparities risk factors helicobacter pylori caga. |
| title | The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo Nation |
| title_full | The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo Nation |
| title_fullStr | The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo Nation |
| title_full_unstemmed | The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo Nation |
| title_short | The prevalence and risk factors of Helicobacter pylori infection and cagA virulence gene carriage in adults in the Navajo Nation |
| title_sort | prevalence and risk factors of helicobacter pylori infection and caga virulence gene carriage in adults in the navajo nation |
| topic | indigenous stomach cancer cancer disparities risk factors helicobacter pylori caga. |
| url | https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/07/e1007.pdf |
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